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Polymorphism of genes of the antioxidant system in the development of predispositions to lung cancer

  • Medical Genetics
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Abstract

We analyzed the polymorphic loci in the genes of the antioxidant system enzymes, such as GSTP1 (313A>G and 341C>T), MnSOD (47С>Т), GPx1 (599C>T), and CAT (–262C>>T), among 497 residents of Kemerovo oblast (Western Siberia, Russia). The analysis of the single-locus effects demonstrated a significant protective effect of the major C allele in the GPx1 (599C>T) locus. The MDR analysis of the gene-gene interactions showed that the GPx1 and the CAT genes work in close cooperation and mutually reinforce the risk of development of squamous cell lung cancer among the inhabitants of the industrial region.

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Author information

Authors and Affiliations

  1. Federal Research Center of Coal and Coal Chemistry, Siberian Branch, Russian Academy of Sciences, Kemerovo, 650065, Russia

    R. A. Titov, V. I. Minina, O. A. Soboleva, A. V. Ryzhkova, Yu. E. Kulemin & E. N. Voronina

  2. Department of Genetics, Kemerovo State University, Kemerovo, 650043, Russia

    V. I. Minina & Yu. E. Kulemin

  3. Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia

    E. N. Voronina

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  1. R. A. Titov
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  2. V. I. Minina
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  3. O. A. Soboleva
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  4. A. V. Ryzhkova
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  5. Yu. E. Kulemin
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  6. E. N. Voronina
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Correspondence to R. A. Titov.

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Original Russian Text © R.A. Titov, V.I. Minina, O.A. Soboleva, A.V. Ryzhkova, Yu.E. Kulemin, E.N. Voronina, 2017, published in Genetika, 2017, Vol. 53, No. 8, pp. 952–959.

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Titov, R.A., Minina, V.I., Soboleva, O.A. et al. Polymorphism of genes of the antioxidant system in the development of predispositions to lung cancer. Russ J Genet 53, 903–909 (2017). https://doi.org/10.1134/S1022795417080117

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  • DOI: https://doi.org/10.1134/S1022795417080117

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