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Manganese superoxide dismutase Ala-9Val mitochondrial targeting sequence polymorphism in systemic lupus erythematosus in Poland

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Abstract

Systemic lupus erythematosus (SLE) is a chronic and progressive autoimmune disease in which reactive oxygen species contribute to pathogenesis. We analysed the distribution of manganese superoxide dismutase (MnSOD 2 ) 47C>T (Ala-9Val) functional polymorphic variants within the mitochondrial targeting sequence in SLE patients (n = 102) and controls (n = 199). We did not find significant differences in the distribution of MnSOD 2 47C>T polymorphic variants in SLE patients and controls. However, we found that MnSOD2 Val/Val genotype (recessive model) showed a significant association with Raynaud’s phenomenon, odds ratio (OR) = 12.000 [95% confidence interval (CI) = 2.315–62.193], p = 0.0015. We also found that the MnSOD2 Val/Val genotype contributes to immunologic manifestations, OR = 2.957 (95% CI = 1.207–7.243), p = 0.0222, and anti-dsDNA antibody presence OR = 3.365 (95% CI = 1.364–8.304), p = 0.0107, in patients. Our observations indicate that MnSOD2 Val/Val variant can be linked to some clinical manifestations in patients with SLE.

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Acknowledgements

The technical assistance of Ms. Agnieszka Mikuczewska is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, 6 Święcickiego St., 60-781, Poznań, Poland

    Adam Sobkowiak, Margarita Lianeri & Paweł P. Jagodziński

  2. Institute of Rheumatology, Warsaw, Poland

    Mariusz Wudarski & Jan K. Łącki

Authors
  1. Adam Sobkowiak
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  2. Margarita Lianeri
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  3. Mariusz Wudarski
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  4. Jan K. Łącki
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  5. Paweł P. Jagodziński
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Correspondence to Paweł P. Jagodziński.

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Sobkowiak, A., Lianeri, M., Wudarski, M. et al. Manganese superoxide dismutase Ala-9Val mitochondrial targeting sequence polymorphism in systemic lupus erythematosus in Poland. Clin Rheumatol 27, 827–831 (2008). https://doi.org/10.1007/s10067-007-0796-6

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  • DOI: https://doi.org/10.1007/s10067-007-0796-6

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