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Mutation induction in the mouse and human germline

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Abstract

The review describes the effects of exposure to mutagens on mutation induction in human and mouse germlines. The results of studies that evaluated inductions of mutations in human families subjected to irradiation are presented and discussed. The effects of exposure to mutagens on mutation induction in the mouse germline are also considered. We analyze and discuss the recent data on the genome-wide effects of irradiation on mutation induction in the mouse germline obtained by next-generation sequencing and comparative genome hybridization.

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  1. Department of Genetics, Leicester University, Leicester, LEI 7RH, United Kingdom

    Yu. E. Dubrova

  2. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 119991, Russia

    Yu. E. Dubrova

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Original Russian Text © Yu.E. Dubrova, 2016, published in Genetika, 2016, Vol. 52, No. 1, pp. 24–36.

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Dubrova, Y.E. Mutation induction in the mouse and human germline. Russ J Genet 52, 17–28 (2016). https://doi.org/10.1134/S1022795416010038

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