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On the role of gene of SER-4 serotonin receptor in thermotolerance of Caenorhabditis elegans behavior

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Abstract

Serotonin reduces the behavior tolerance of Caenorhabditis elegans of the N2 wild-type strain (swimming induced by the mechanical stimulus) to a temperature of 36°C. The sensitivity to the serotonin influence on the behavior thermotolerance remains intact in strains with null mutations of mod-1(ok103) and ser-1(ok345) serotonin receptor genes, and is almost completely lost in the ser-4(ok512) strain with null mutation in the gene of the SER-4 serotonin receptor, which is a homologue of 5-HT1 mammalian serotonin receptor. In addition, nematodes of the ser-4(ok512) strain have high behavior thermotolerance in the absence of the exogenous serotonin compared to the N2 strain. These data indicate the involvement of the ser-4 gene in the serotonin regulation of the tolerance of C. elegance nervous system functions to hyperthermia.

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References

  1. Bouchama, A. and Knochel, J.P., Heat Stroke, N. Engl. J. Med., 2002, vol. 346, pp. 1978–1988.

    Article  PubMed  CAS  Google Scholar 

  2. Robertson, R.M., Modulation of Neural Circuit Operation by Prior Environmental Stress, Integr. Comp. Biol., 2004, vol. 44, pp. 21–27.

    Article  PubMed  Google Scholar 

  3. Robertson, R.M., Thermal Stress and Neural Function: Adaptive Mechanisms in Insect Model Systems, J. Therm. Biol., 2004, vol. 29, pp. 351–358.

    Article  CAS  Google Scholar 

  4. Kalinnikova, T.B., Kolsanova, R.R., and Gainutdinov, M.Kh., Caenorhabditis elegans as a Convenient Model Organism for Understanding Heat Stress Effects upon Intact Nervous System, Heat Stress: Causes, Treatment and Prevention, Josipovic, S. and Ludwig, E.N.Y, Eds., New York: Nova Science, 2012, pp. 113–140.

    Google Scholar 

  5. Hartig, P., Molecular Biology and Transductional Characteristics of 5-HT Receptors, Serotoninergic Neurons and 5-HT Receptors in the CNS, Baumgarten, H., Ed., Berlin: Springer-Verlag, 1997, pp. 175–212.

    Google Scholar 

  6. Carre-Pierrat, M., Baillie, D., Johnsen, R., et al., Characterization of Caenorhabditis elegans G Protein-Coupled Serotonin Receptors, Invert. Neurosci., 2006, vol. 6, pp. 189–205.

    Article  PubMed  CAS  Google Scholar 

  7. Murakami, H. and Murakami, S., Serotonin Receptors Antagonistically Modulate Caenorhabditis elegans Longevity, Aging Cell, 2007, vol. 6, pp. 483–488.

    Article  PubMed  CAS  Google Scholar 

  8. Buhot, M.S., Martin, S., and Segu, L., Role of Serotonin in Memory Impairment, Ann. Med., 2000, vol. 32, pp. 210–221.

    Article  PubMed  CAS  Google Scholar 

  9. Dernovici, S., Starc, T., Dent, J.A., and Ribeiro, P., The Serotonin Receptor SER-1 (5HT2ce) Contributes to the Regulation of Locomotion in Caenorhabditis elegans, Dev. Neurobiol., 2007, pp. 189–204.

    Google Scholar 

  10. Hobson, R.J., Hapiak, V.M., Xiao, H., et al., SER-7, a Caenorhabditis elegans 5-HT7-Like Receptor, Is Essential for the 5-HT Stimulation of Pharyngeal Pumping and Egg Laying, Genetics, 2006, vol. 172, pp. 159–169.

    Article  PubMed  CAS  Google Scholar 

  11. Hapiak, V.M., Hobson, R.J., Hughes, L., et al., Dual Excitatory and Inhibitory Serotonergic Inputs Modulate Egg Laying in Caenorhabditis elegans, Genetics, 2009, vol. 181, pp. 153–163.

    Article  PubMed  CAS  Google Scholar 

  12. Harris, G.P., Hapiak, V.M., Wragg, R.T., et al., Three Distinct Amine Receptors Operating at Different Levels within the Locomotory Circuit Are Each Essential for the Serotonergic Modulation of Chemosensation in Caenorhabditis elegans, J. Neurosci., 2009, vol. 29, pp. 1446–1456.

    Article  PubMed  CAS  Google Scholar 

  13. Carnell, L., Illi, J., Hong, S.W., and McIntire, S., The G-Protein-Coupled Serotonin Receptor SER-1 Regulates Egg Laying and Male Mating Behaviors in Caenorhabditis elegans, J. Neurosci., 2005, vol. 25, pp. 10671–10681.

    Article  PubMed  CAS  Google Scholar 

  14. Weiger, W.A., Serotonergic Modulation of Behavior: A Phylogenetic Overview, Biol. Rev. Camb. Philos. Soc., 1997, vol. 72, pp. 61–95.

    Article  PubMed  CAS  Google Scholar 

  15. Schloss, P. and Williams, D.C., The Serotonin Transporter: A Primary Target for Antidepressant Drugs, J. Psychopharmacol., 1998, vol. 12, pp. 115–121.

    Article  PubMed  CAS  Google Scholar 

  16. Brenner, S., The Genetics of Caenorhabditis elegans, Genetics, 1974, vol. 77, pp. 71–94.

    PubMed  CAS  Google Scholar 

  17. Plokhinskii, N.A., Algoritmy biometrii (Algorithms of Biometry), Moscow: Izd. Mosk. Univ., 1980.

    Google Scholar 

  18. Ranganathan, R., Sawin, E.R., Trent, C., and Horvitz, H.R., Mutations in the Caenorhabditis elegans Serotonin Reuptake Transporter MOD-5 Reveal Serotonin-Dependent and -Independent Activities of Fluoxetine, J. Neurosci., 2001, vol. 21, pp. 5871–5884.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute for Problems of Ecology and Mineral Wealth Use, Tatarstan Academy of Sciences, Kazan, 420087, Russia

    T. B. Kalinnikova, R. R. Kolsanova, R. R. Shagidullin, E. B. Osipova & M. Kh. Gaynutdinov

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  1. T. B. Kalinnikova
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  2. R. R. Kolsanova
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  3. R. R. Shagidullin
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  4. E. B. Osipova
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  5. M. Kh. Gaynutdinov
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Correspondence to T. B. Kalinnikova.

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Original Russian Text © T.B. Kalinnikova, R.R. Kolsanova, R.R. Shagidullin, E.B. Osipova, M.Kh. Gaynutdinov, 2013, published in Genetika, 2013, Vol. 49, No. 3, pp. 415–419.

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Kalinnikova, T.B., Kolsanova, R.R., Shagidullin, R.R. et al. On the role of gene of SER-4 serotonin receptor in thermotolerance of Caenorhabditis elegans behavior. Russ J Genet 49, 363–366 (2013). https://doi.org/10.1134/S1022795413030083

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  • DOI: https://doi.org/10.1134/S1022795413030083

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