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Infectious symbiology: A new understanding of old problems

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Abstract

The current century has seen the discovery of a new trend in science, infectious symbiology, which studies ambiguous interactions between microbes and humans (from peaceful contacts to direct antagonism). What underlies these interrelations? What do such different outcomes depend on? These are important questions for Homo sapiens because, only after having deciphered the mechanisms of these outcomes (from health to disease), will we become able to control them. Here one naturally recalls I.P. Pavlov, who held that “explanation is not the goal of science. The goal of science is power.” However, to rule this world, humans need knowledge. Although the problems of infectious pathology remain the same, we should take a fresh look at them and use this knowledge to preserve our own health. The material proposed here is a new look at old problems and at the opening prospects.

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References

  1. J. Lederberg, “Infectious history,” Science 288 (5464), 287 (2000).

    Article  Google Scholar 

  2. L. V. Hooper, T. Midtvedt, and J. I. Gordon, “How host-microbial interactions shape the nutrient environment of the mammalian intestine,” Ann. Rev. Nutr. 22, 283 (2011).

    Article  Google Scholar 

  3. H. A. de Bary, Microbiological Therapy (Arnebiya, Moscow, 2003).

    Google Scholar 

  4. O. V. Bukharin, E. S. Lobakova, N. V. Nemtseva, and S. V. Cherkasov, Associative Symbiosis (Izd. UrO RAN, Yekaterinburg, 2007).

    Google Scholar 

  5. O. V. Bukharin, “Infection–modeling system of associative symbiosis,” Zh. Mikrobiol., Epidemiol., Immunobiol., No. 1, 83 (2009).

    Google Scholar 

  6. A. K. Benson, S. A. Kell, R. Legge, et al., “Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors,” Proc. Natl. Acad. Sci. U. S. A. 107, 18933 (2010).

    Article  CAS  Google Scholar 

  7. W. R. Wikoff, A. T. Anfora, J. Liu, et al., “Metabolimics analysis reveals large effects of gut microflora on mammalian flood metabolites,” Proc. Nat. Acad. Sci. U. S. A. 106, 3698 (2009).

    Article  CAS  Google Scholar 

  8. L. Margulis, Symbiosis in Cell Evolution: Life and Its Environment on the Early Earth (Freeman, San Francisco, 1981).

    Google Scholar 

  9. M. Arumugam, J. Raes, E. Pelletier, et al., “Enterotypes of the human gut microbiome,” Nature 473, 174 (2011).

    Article  CAS  Google Scholar 

  10. J. Qin, R. Li, J. Raes, et al., “A human gut microbial gene catalogue established by metagenomic sequences,” Nature 464, 59 (2010).

    Article  CAS  Google Scholar 

  11. I. Cho and M. J. Blaser, “The human microbiome: At the interface of health and disease,” Nat. Rev. Genet. 13 (14), 260 (2012).

    CAS  Google Scholar 

  12. K. E. Nelson, Metagenomics of the Human Body (Springer, New York, 2011).

    Book  Google Scholar 

  13. J. M. Wong, R. de Souza, C. W. Kendall, et al., “Colonic health: Fermentation and short chain fatty acids,” J. Clin. Gastroenterol. 40, 235 (2006).

    Article  CAS  Google Scholar 

  14. O. V. Bukharin, N. B. Perunova, and E. V. Ivanova, Bifidoflola in Human Associative Symbiosis (Izd. UrO RAN, Yekaterinburg, 2014) [in Russian].

    Google Scholar 

  15. O. V. Bukharin and N. B. Perunova, “Symbiotic relations of humans and microorganisms,” Human Physiol. 38 (1), 108 (2012).

    Article  Google Scholar 

  16. O. V. Bukharin, E. V. Ivanova, N. B. Perunova, and I. N. Chainikova, “The role of bifidobacteria in the formation of human immune homeostasis,” Zh. Microbiol., Epidemiol., Immunobiol., No. 6, 98 (2015).

    Google Scholar 

  17. B. N. Kokryakov, Essays on Inborn Immunity (Nauka, St. Petersburg, 2006) [in Russian].

    Google Scholar 

  18. O. V. Bukharin and N. B. Perunova, Microsymbiocenosis (Izd. UrO RAN, Yekaterinburg, 2014) [in Russian].

    Google Scholar 

  19. N. B. Perunova, Bioregulation of microsymbionts in the human gut microsymbiocenosis, Extended Abstract of Doctoral Dissertation in Medical Science (Orenburg, 2011).

    Google Scholar 

  20. O. E. Chelpachenko, The pathogenetic importance of intestinal microbiocenosis in children with the conjunctive tissue dysplasia syndrome and possible ways of correcting it, Extended Abstract of Doctoral Dissertation in Medical Science (Orenburg, 2003).

    Google Scholar 

  21. E. A. Kremleva, O. D. Konstantinova, and S. V. Cherkasov, “Microecological condition of the vaginal biotope in patients opposite to fertility in the ECO program,” Med. Al’manakh, No. 4, 95 (2010).

    Google Scholar 

  22. S. V. Shirshov, Immune Control Mechanisms for Reproduction Processes (Izd. UrO RAN, Yekaterinburg, 1999) [in Russian].

    Google Scholar 

  23. O. V. Bukharin, N. B. Perunova, O. E. Chelpachenko, et al., “The role of intermicrobial interactions Candida spp. under the pathology of the locomotor apparatus in children,” Probl. Med. Mikologii, No. 3, 14 (2013).

    Google Scholar 

  24. N. S. Karpunina, B. A. Bakhmet’ev, and M. V. Zaikina, “Signs of microbial sensibilization in patients with various cardiovascular diseases,” Zh. Microbiol., Epidemiol., Immunobiol., No. 1, 75 (2015).

    Google Scholar 

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Authors and Affiliations

  1. Institute for Cellular and Intracellular Symbiosis, Ural Branch, Russian Academy of Sciences, Orenburg, Russia

    O. V. Bukharin

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  1. O. V. Bukharin
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Correspondence to O. V. Bukharin.

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Original Russian Text © O.V. Bukharin, 2016, published in Vestnik Rossiiskoi Akademii Nauk, 2016, Vol. 86, No. 10, pp. 915–920.

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Bukharin, O.V. Infectious symbiology: A new understanding of old problems. Her. Russ. Acad. Sci. 86, 396–401 (2016). https://doi.org/10.1134/S1019331616040018

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