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DNA glycosylases: The main elements of the DNA repair system

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Abstract

It is assumed that the process of complete cell regeneration in the human body takes eight to ten years. Cellular DNA is responsible for the preservation of the cells’ identity. What happens, however, when DNA molecules are damaged? Studies of DNA glycosylases help not only to establish restoration mechanisms but also to understand the cause of some diseases, to specify methods of regulating the activity of genes, and to create new instruments for laboratory analysis. The article published below is based on a scientific paper presented by the author at a meeting of the Presidium of the RAS Siberian Branch.

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References

  1. E. C. Friedberg, G. C. Walker, W. Siede, et al., DNA Repair and Mutagenesis (ASM Press, Washington, 2006).

    Google Scholar 

  2. D. O. Zharkov, “Genome’s Sentinels,” Nauka Iz Pervykh Ruk, No. 4 (2009).

    Google Scholar 

  3. D. O. Zharkov, “Base Excision DNA Repair,” Cell. Mol. Life Sci. 65(10) (2008).

    Google Scholar 

  4. B. Halliwell and J. M. C. Gutteridge, Free Radicals in Biology and Medicine, 4 ed. (Oxford Univ. Press, Oxford, 2007).

    Google Scholar 

  5. C. Von Sonntag, Free-Radical-Induced DNA Damage and Its Repair: A Chemical Perspective (Springer, Berlin, 2006).

    Google Scholar 

  6. D. O. Zharkov, “Riddles of the “Rusty” DNA,” Nauka Iz Pervykh Ruk,” No. 6 (2006).

    Google Scholar 

  7. V. S. Sidorenko and D. O. Zharkov, “Role of Base Excision Repair DNA Glycosylases in Hereditary and Infectious Human Diseases,” Mol. Biol. 42(5), 794 (2008).

    Article  Google Scholar 

  8. H. Wu and Y. Zhang, “Mechanisms and Functions of Tet Protein-Mediated 5-Methylcytosine Oxidation,” Genes Dev. 25(23) (2011).

    Google Scholar 

  9. D. O. Zharkov, “Structure and Conformational Dynamics of Base Excision Repair DNA Glycosylases,” Mol. Biol. 41(5), 702 (2007).

    Article  Google Scholar 

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Authors
  1. Dmitrii Olegovich Zharkov
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Additional information

Original Russian Text © D.O. Zharkov, 2013, published in Vestnik Rossiiskoi Akademii Nauk, 2013, Vol. 83, No. 2, pp. 112–119.

Dmitrii Olegovich Zharkov, Dr. Sci. (Biol.), is head of the biopolymers interaction group at the Institute of Chemical Biology and Fundamental Medicine, RAS Siberian Branch.

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Zharkov, D.O. DNA glycosylases: The main elements of the DNA repair system. Her. Russ. Acad. Sci. 83, 38–45 (2013). https://doi.org/10.1134/S1019331613010097

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  • DOI: https://doi.org/10.1134/S1019331613010097

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