Abstract
Innate immunity was investigated in six volunteers aged 28 to 44 years participating in the experiment with 120-day isolation in a controlled environment. Peripheral blood samples collected during isolation were analyzed to determine the content of monocytes and granulocytes expressing intracellular (TLR3, TLR8, TLR9) and surface (TLR1, TLR2, TLR4, TLR5, TLR6) TLRs, as well as the content of natural killer lymphocytes (CD3–CD16+CD56+). The system of pattern-recognition receptors of innate immunity cells exhibited heterogenic reaction to isolation with predominant activation throughout the entire experimental exposure. The revealed changes seem to reflect a complex adaptive process that occurs in the human immune system during the establishment of a dynamic balance with extreme environmental factors, including response to endogenous and exogenous immune stimuli.
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This study was supported by the Russian Science Foundation, project no. 18-75-10 086.
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All procedures performed in studies involving human participants were in accordance with the biomedical ethics principles formulated in the 1964 Helsinki Declaration and its later amendments and approved by the local bioethical committee of the Institute of Biomedical Problems (Moscow).
Conflict of interest. The authors declare that they do not have a conflict of interest.
Informed consent. Each study participant provided a voluntary written informed consent signed by him after explaining to him the potential risks and benefits, as well as the nature of the upcoming study.
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Translated by E. Babchenko
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Ponomarev, S.A., Shulguina, S.M., Kalinin, S.A. et al. State of the Human Innate Immunity Cell Component during 120-Day Isolation in a Pressurized Module. Hum Physiol 48, 827–832 (2022). https://doi.org/10.1134/S036211972207009X
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DOI: https://doi.org/10.1134/S036211972207009X