Abstract
We studied the cytokine profile in ten healthy volunteers participating in the experiment with a 21-day-long dry immersion (DI). The results of these studies revealed pronounced individual differences in the immune system response to the prolonged exposure to simulated microgravity. It has been shown that the stay under the DI conditions leads to changes in the plasma cytokine levels, primarily towards their higher concentrations, and TH1/TH2 balance, as well as the activation potential of monocytes, which is manifested as a decrease in the synthesis of cytokines by cells with the TLR+CD14+ phenotype in response to stimulation by various ligands in vitro.
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This study was supported by the Russian Science Foundation, project no. 18-75-10086.
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Statement of compliance with standards of research involving humans as subjects. All studies were carried out in accordance with the principles of biomedical ethics formulated in the 1964 Helsinki Declaration and its later amendments and approved by the Commission on Biomedical Ethics of the Institute of Biomedical Problems of the Russian Academy of Sciences (Moscow). Each study participant submitted voluntary written informed consent, signed after receiving explanation of potential risks and benefits, as well as the nature of the forthcoming study.
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Ponomarev, S.A., Rykova, M.P., Antropova, E.N. et al. Cytokine Profile in Volunteers during a 21-Day Dry Immersion without Countermeasures. Hum Physiol 46, 175–181 (2020). https://doi.org/10.1134/S0362119720020139
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DOI: https://doi.org/10.1134/S0362119720020139