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Relationship between the Imbalance of Macro- and Microelement Homeostasis System and the Development of Structural Disintegration in the Major Arteries of the Head

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Abstract

We have studied the quantitative changes in the contents of macro- and microelements and the linear correlations between their concentrations in serum, ultrafiltrate and urine during the structural transformation of blood vessels, with dissection of the main arteries of the head serving as an example. We observed a decrease in the content of serum copper and an increase in its ultrafiltered fraction. It was found that the level of copper upon dissection of the main arteries of the head was most informative in serum and its ultrafiltrate. Serum iron and zinc levels and their ultrafiltered fractions were balanced. The ultrafiltered fraction of serum magnesium was decreased. The imbalance of serum Ca/Mg ratio was due to physiologically active ionized forms.

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Funding

The study was supported by the basic budgetary financing of research works.

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Authors and Affiliations

  1. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia

    O. V. Protasova, I. A. Maksimova & Yu. F. Krupyanskii

  2. Research Center of Neurology, Russian Academy of Sciences, Moscow, Russia

    L. A. Dobrynina, L. A. Kalashnikova & M. V. Gubanova

Authors
  1. O. V. Protasova
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  2. I. A. Maksimova
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  3. L. A. Dobrynina
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  4. L. A. Kalashnikova
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  5. M. V. Gubanova
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  6. Yu. F. Krupyanskii
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Corresponding author

Correspondence to O. V. Protasova.

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Conflict of interests. The authors declare that they have no conflict of interest.

Statement of compliance with standards of research involving humans as subjects. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants involved in the study.

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Translated by E.V. Makeeva

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Protasova, O.V., Maksimova, I.A., Dobrynina, L.A. et al. Relationship between the Imbalance of Macro- and Microelement Homeostasis System and the Development of Structural Disintegration in the Major Arteries of the Head. Hum Physiol 46, 417–422 (2020). https://doi.org/10.1134/S0362119720020140

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  • DOI: https://doi.org/10.1134/S0362119720020140

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