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Epac Proteins and Their Role in the Physiological and Pathological Processes in the Cardiovascular System. Part 1: The Role of Epac Proteins in the Physiological and Pathological Processes of the Vasculature

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Abstract

The article contains a review of published data on the contribution of Epac proteins to the physiology and pathological processes of the cardiovascular system. Part 1 of the review is focused on the structure of regulatory Epac proteins and their role in the regulation of vascular tone and permeability, angiogenesis, proliferation of endotheliocytes and smooth myocytes, and pathogenesis of vascular disorders.

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ACKNOWLEDGMENTS

We are sincerely grateful to Yu.V. Vakhitova, Corresponding Member of the Russian Academy of Sciences, Principal Research Scientist at the Zakusov Institute of Pharmacology (Moscow) for her advisory assistance in work on this literature review and V.V. Barchukov, Research Associate at the Zakusov Institute of Pharmacology, for his assistance in presentation of this work.

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  1. Zakusov Institute of Pharmacology, Moscow, Russia

    S. A. Kryzhanovsky, T. D. Nikiforova & A. D. Durnev

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  1. S. A. Kryzhanovsky
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Kryzhanovsky, S.A., Nikiforova, T.D. & Durnev, A.D. Epac Proteins and Their Role in the Physiological and Pathological Processes in the Cardiovascular System. Part 1: The Role of Epac Proteins in the Physiological and Pathological Processes of the Vasculature. Hum Physiol 46, 200–215 (2020). https://doi.org/10.1134/S0362119720020073

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