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The State of the System of Signaling Pattern Recognition Receptors of Monocytes and Granulocytes in the Cosmonauts’ Peripheral Blood before and after Long-Term Flights on Board the International Space Station

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Abstract

The system of signaling pattern recognition receptors was studied in eight cosmonauts at the ages from 35 to 56 years before and after long-term space flights (SFs) on board the International Space Station (ISS). The peripheral blood samples were analyzed for the content of monocytes and granulocytes that express the signaling pattern recognition Toll-like receptors (TLRs) with surface (TLR1, TLR2, TLR4, TLR5, and TLR6) and intracellular (TLR3, TLR8, and TLR9) localization. The serum concentration of basic ligands of TLR2 (HSP60) and TLR4 (HSP70 and HMGB1) were also measured. The results of the studies showed a growth of the HSP60, HSP70, and HMGB1 concentrations on the first day after long-term flight. The increase in the concentration of endogenous ligands was followed by a growth of the number of both monocytes and granulocytes that express the respective pattern recognition receptors, TLR2 and TLR4, in the overwhelming majority of the examined cosmonauts. Thesse relationships suggest that changes in the system of signaling pattern recognition receptors may be due to the prevailing influence of endogenous ligands in response to the effect of long-term spaceflight factors on the human body.

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References

  1. Khaitov, R.M., Pashchenkov, M.V., and Pinegin, B.V., The role of pattern-recognition receptors in innate and adaptive immunity, Immunologiya, 2009, vol. 1, pp. 66–80.

    Google Scholar 

  2. Medzhitov, R. and Janeway, C., Innate immunity, N. Engl. J. Med., 2000, vol. 343, pp. 338–344.

    Article  CAS  PubMed  Google Scholar 

  3. Stowe, R.P., Sams, C.F., Mehta, S.K., et al., Leukocyte subsets and neutrophile function after short-term spaceflight, J. Leukocyte Biol., 1999, vol. 65, p. 179.

    Article  CAS  PubMed  Google Scholar 

  4. Yanssens, S. and Beyard, R., Role of Toll-like receptors in pathogen recognition, Clin. Microbiol. Rev., 2003, vol. 16, pp. 1–19.

    Article  Google Scholar 

  5. Akira, S., Toll-like receptor signaling, J. Biol. Chem., 2003, vol. 278, pp. 38105–38108.

    Article  CAS  PubMed  Google Scholar 

  6. Backhed, F., Normark, S., Schweda, E.K., et al., Structural requirements for TLR4-mediated LPS signaling: a biological role for LPS modifications, Microbes Infect., 2003, no. 5, pp. 1057–1063.

    Article  CAS  PubMed  Google Scholar 

  7. Gargo, A., Tominac, M., Krsulovic-Hresic, V., et al., Increased Toll-like receptors 4 expression in infants with respiratory syncytial virus bronchiolitis, J. Clin. Exp. Immunol., 2004, vol. 135, no. 2, pp. 267.

    Article  Google Scholar 

  8. Medzhitov, R., Toll-like receptors and innate immunity, Nat. Rev. Immunol., 2001, vol. 1, no. 2, pp. 135–145.

    Article  CAS  PubMed  Google Scholar 

  9. Konstantinova, I.V., The immune system in extreme conditions, in Kosmicheskaya immunologiya (Space Immunology), Moscow: Nauka, 1988, pp. 1–289.

    Google Scholar 

  10. Rykova, M.P., Antropova, E.N., and Meshkov, D.O., Results of cosmonauts’ immunological examination during re-adaptation after space flights, in Orbital’naya stantsiya “Mir” (Mir Orbital Station), Moscow: Inst. Med.-Biol. Probl., Ross. Akad. Nauk, 2001, vol. 1, pp. 615–618.

    Google Scholar 

  11. Crucian, B., Stowe, R., and Mehta, S., Immune system dysregulation occurs during short duration spaceflight on board the space shuttle, J. Clin. Immunol., 2013, vol. 33, no. 2, pp. 456–465.

    Article  CAS  PubMed  Google Scholar 

  12. Konstantinova, I.V., Rykova, M.P., Lesnyak, A.T., et al., Immune changes during long-duration missions, J. Leukocyte Biol., 1993, vol. 54, p. 189.

    Article  CAS  PubMed  Google Scholar 

  13. Crucian, B.E., Stowe, R.P., Pierson, D.L., et al., Immune system dysregulation following short-vs longduration spaceflight, Aviat. Space Environ. Med., 2008, vol. 79, p. 835.

    Article  PubMed  Google Scholar 

  14. Meehan, R.T., Whitson, P., and Sams, C.F., The role of psychoneuroendocrine factors on spaceflightinduced immunological alterations, J. Leukocyte Biol., 1993, vol. 54, p. 236.

    Article  CAS  PubMed  Google Scholar 

  15. Morukov, B., Rykova, M., Antropova, E., et al., T-cell immunity and cytokine production in cosmonauts after long-duration space flights, Acta Astronaut., 2011, vol. 68, pp. 739–746.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia

    S. A. Ponomarev, T. A. Berendeeva, S. A. Kalinin & A. V. Muranova

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  1. S. A. Ponomarev
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  2. T. A. Berendeeva
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  3. S. A. Kalinin
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  4. A. V. Muranova
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Correspondence to S. A. Ponomarev.

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Original Russian Text © S.A. Ponomarev, T.A. Berendeeva, S.A. Kalinin, A.V. Muranova, 2016, published in Aviakosmicheskaya i Ekologicheskaya Meditsina, 2016, Vol. 50, No. 5, pp. 18–23.

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Ponomarev, S.A., Berendeeva, T.A., Kalinin, S.A. et al. The State of the System of Signaling Pattern Recognition Receptors of Monocytes and Granulocytes in the Cosmonauts’ Peripheral Blood before and after Long-Term Flights on Board the International Space Station. Hum Physiol 43, 808–812 (2017). https://doi.org/10.1134/S0362119717070167

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  • DOI: https://doi.org/10.1134/S0362119717070167

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