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Analysis of Visual Cognitive Impairments in Schizophrenia at the Early Stages of the Disease and Their Correction by Interactive Virtual Environment

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Abstract

The paper describes the results of studies aimed at evaluating the effect of interactive virtual environments on the visual system, including the magno-and parvo-systems. Analysis was conducted in patients diagnosed with paranoid schizophrenia diagnosed from one to five years ago. Comparative analysis of visual evoked potentials during the perception of images that differed in their semantic (animate/inanimate) and physical characteristics (filtration images at high/low spatial frequencies) was used for the assessment of the impact of virtual environments. The images of objects were filtered via digital filtration for selective effect on the magno-and parvo-channels of the visual system. To evaluate the function of visual perception, the measurement of contrast sensitivity using Gabor elements was used. At the early stages of schizophrenia, the patients exhibited a decrease in the amplitudes of the components of cognitive visual evoked potentials to stimuli filtered at high spatial frequencies and reduced contrast sensitivity at high spatial frequencies. The effect of virtual environments on the visual system resulted in a significant increase in the amplitude of the cognitive components of visual evoked potentials in the paradigm of presentation of images filtered at the high spatial frequencies, which allows the conclusion about a stimulating effect of the virtual environment on the parvo-system functioning. The activation of the magno-system occurred to a lesser extent. The present study represents the findings obtained by the studies of cognitive impairments in schizophrenia and the methods of their correction conducted at the Laboratory of Physiology of Vision of the Pavlov Institute of Physiology of the Russian Academy of Sciences and at the Laboratory of Neurobiology of Action Programming of the Bechtereva Institute of the Human Brain of the Russian Academy of Sciences.

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Authors and Affiliations

  1. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    S. V. Muraveva, G. A. Moiseenko, S. V. Pronin, E. Yu. Shelepin & Yu. E. Shelepin

  2. Bechtereva Institute of the Human Brain, Russian Academy of Sciences, St. Petersburg, Russia

    M. V. Pronina, Yu. I. Polyakov & Yu. D. Kropotov

  3. St. Petersburg State Pediatric Medical University, St. Petersburg, Russia

    A. N. Pnevskaya

Authors
  1. S. V. Muraveva
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  2. M. V. Pronina
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  3. G. A. Moiseenko
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  4. A. N. Pnevskaya
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  5. Yu. I. Polyakov
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  6. Yu. D. Kropotov
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  7. S. V. Pronin
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  8. E. Yu. Shelepin
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  9. Yu. E. Shelepin
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Correspondence to S. V. Muraveva.

Additional information

Original Russian Text © S.V. Muraveva, M.V. Pronina, G.A. Moiseenko, A.N. Pnevskaya, Yu.I. Polyakov, Yu.D. Kropotov, S.V. Pronin, E.Yu. Shelepin, Yu.E. Shelepin, 2017, published in Fiziologiya Cheloveka, 2017, Vol. 43, No. 6, pp. 24–36.

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Muraveva, S.V., Pronina, M.V., Moiseenko, G.A. et al. Analysis of Visual Cognitive Impairments in Schizophrenia at the Early Stages of the Disease and Their Correction by Interactive Virtual Environment. Hum Physiol 43, 625–636 (2017). https://doi.org/10.1134/S0362119717060056

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  • DOI: https://doi.org/10.1134/S0362119717060056

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