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Association between relative bone mass and vitamin D receptor gene polymorphism

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Abstract

The paper reports a search for association between the relative bone tissue mass (percent of total body mass, %BT) and FokI (rs10735810), BsmI (rs1544410), and TaqαI (rs731236) vitamin D receptor gene polymorphisms. The group of apparently healthy young adults born in the central and northern regions of European Russia included 61 men and 60 women aged 16–23 years. No statistical association was detected between the FokI polymorphism and %BT. The carriers of the BsmI *A allele exhibited a higher %BT (p = 0.0172) compared to the subjects bearing the BsmI *G*G allele. The subjects with the *C*C TaqαI genotype were characterized by increased %BT compared to the carriers of the *T allele (p = 0.0018). The data are in good correspondence with the results obtained in the studies involving apparently healthy representatives of Central European and Northern European populations of the corresponding age.

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Authors and Affiliations

  1. Moscow State University, Moscow, 119992, Russia

    A. I. Kozlov, G. G. Vershubskaya & M. A. Negasheva

  2. Perm State Humanitarian-Pedagogical University, Perm, 614045, Russia

    A. I. Kozlov

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  1. A. I. Kozlov
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  2. G. G. Vershubskaya
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  3. M. A. Negasheva
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Correspondence to A. I. Kozlov.

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Original Russian Text © A.I. Kozlov, G.G. Vershubskaya, M.A. Negasheva, 2017, published in Fiziologiya Cheloveka, 2017, Vol. 43, No. 3, pp. 96–101.

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Kozlov, A.I., Vershubskaya, G.G. & Negasheva, M.A. Association between relative bone mass and vitamin D receptor gene polymorphism. Hum Physiol 43, 320–325 (2017). https://doi.org/10.1134/S0362119717030100

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