Abstract
The effects of the administration of desmopressin, a synthesized analog of antidiuretic hormone, together with a water-salt supplement on the renal function and orthostatic stability were investigated. Six healthy men spent 12 h in the head-down tilt (HDT) position. It was demonstrated that administration of desmopressin led to normalization of salt and water homeostasis; moreover, the tolerance of the standard 20 min passive standing test was improved significantly. These observations indicate that intake of the synthetic vasopressin analog combined with water-salt supplement counteracts hypohydration of the body during HDT and improved orthostatic tolerance.
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References
Vander, A., Renal Physiology, New York: McGraw-Hill Medical, 2002.
Glantz, S., Primer of Biostatistics, New York: McGraw-Hill Medical, 1997.
Grigor’ev, A.I., Buravkova, L.B., Larina, I.M., and Natochin, Yu.V., Water and Electrolyte Metabolism after Administration of Desmopressin Instead of Vasopressin, Ross. Fiziol. Zh. im. I.M. Sechenova, 2004, vol. 90, no. 8, p. 60.
Grigor’ev, A.I., Larina, I.M., Buravkova, L.B., et al., Antidiuretic Response of Kidneys to Different Modes of Vasopressin Administration, Hum. Physiol., 2003, vol. 29, no. 3, p. 341.
Grigor’ev, A.I. and Noskov, V.B., Assessment of the Efficacy of the Water-Salt Supplement during Space Flights of the Mir Orbital Station, Aviakosm. Ekol. Med., 2001, vol. 35, no. 5, p. 11.
Egorov, A.D., Mechanisms of Decrease in Orthostatic Stability during Space Flights, Aviakosm. Ekol. Med., 2001, vol. 35, no. 6, p. 3.
Larina, I.M., Noskov, V.B., Nichiporuk I.A., et al. Impact of desmopressin on the water and salt homeostasis and orthostatic tolerance in the conditions of HDT. Aviakosm. Ekol. Med., 2009, vol. 43, no. 1, p. 68.
Metodiki issledovanii v tselyakh vrachebnoletnoi ekspertizy (Posobie dlya chlenov vrachebnoletnykh komissii) (Examination Methodology for Medical-Flight Assessment: Guidelines for the Members of Medical-Flight Commissions), Moscow, 1995.
Natochin, Yu.V., Grigor’ev, A.I., Buravkova, L.B., et al., Antidiuretic Reaction of the Human and Rat Kidney to Peroral Administration of Arginine-Vasopressin and Desmopressin, Ross. Fiziol. Zh. im. I.M. Sechenova, 2003, vol. 89, no. 2, p. 184.
Noskov, V.B., Correction of the Level of Hydration of the Human Body at Various Stages of Space Flight, Aviakosm. Ekol. Med., 2003, vol. 37, no. 2, p. 19.
Noskov, V.B., Nikolaev, D.V., Tuykin, S.A., et al., Portable Impedance Meter for Assessing the Amount of Body Fluids during Space Flights, Med Tekh., 2007, no. 2, p. 45.
Noskov, V.B., Nichiporuk, I.A., and Grigor’ev. A.I., Dynamics of Liquid Environments and Body Composition under the Conditions of Prolonged Space Flight: Bioimpedance Analysis, Aviakosm. Ekol. Med., 2007, vol. 41, no. 3, p. 3.
Laszlo, Z., Roessler, A., and Hinghofer-Szalkay, H., Cardiovascular and Humoral Readjustment after Different Levels Head-up Tilt in Humans, Aviat. Space Environ. Med., 2001, vol. 72, no. 3, p. 193.
Jackson, E.K. Vasopressin and Other Agents Affecting the Renal Conservation of Water, in The Pharmacological Basis of Therapeutics, Hardman, J.G., Goodman, G.A., and Limbird, L.E., Eds. New York: McGraw-Hill Professional, 1995, p. 715.
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Original Russian Text © V.B. Noskov, I.M. Larina, I. A. Nichiporuk, L.Kh. Pastushkova, G.Yu. Vasilieva, 2010, published in Aviakosmicheskaya i Ekologicheskaya Meditsina, 2010, Vol. 44, No. 5, pp. 32–37.
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Noskov, V.B., Larina, I.M., Nichiporuk, I.A. et al. Evaluation of synthetic antidiuretic hormone as a corrective substance following a head-down tilt. Hum Physiol 38, 781–785 (2012). https://doi.org/10.1134/S0362119712070171
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DOI: https://doi.org/10.1134/S0362119712070171