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Influence of sensory peptidergic innervation on human skin blood flow oscillations in the range 0.047–0.069 Hz

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Abstract

Thirty-six healthy subjects and 65 patients with neurogenic inflammation (complex regional pain syndrome of the hand) or denervation syndromes (after median and ulnar nerve injuries or transplantation of denervated vascularized musculocutaneous autografts), as well as after thoracoscopic sympathectomy, underwent laser Doppler flowmetry with spectral wavelet analysis of the blood flow oscillations in cutaneous microvessels and thermography. It was shown that, along with maintenance of the blood flow oscillations of endothelial genesis, peptidergic sensory nerve fibers (SPFs) are involved in activating independent, including high-amplitude, oscillations in the myogenic range 0.047–0.069 Hz (an average of three to four oscillations per minute). The above-mentioned oscillations were recorded against the background of neurogenic inflammation and nociceptive activation of C afferents after nerve injuries, as well as in the course of functional tests in healthy subjects (the forearm skin electrostimulation test, capsaicin application). Sympathectomy and hyposympathicotonia contributed to their manifestation; they were not detected under the conditions of severe sensory-trophic skin denervation. The appearance of high-amplitude blood flow oscillations in human skin microvessels at a frequency of 0.047–0.069 Hz may serve as an objective criterion of SPF activation.

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  1. Priorov Central Research Institute of Traumatology and Orthopedics, Moscow, 127299, Russia

    A. I. Krupatkin

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  1. A. I. Krupatkin
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Original Russian Text © A.I. Krupatkin, 2007, published in Fiziologiya Cheloveka, 2007, Vol. 33, No. 3, pp. 48–54.

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Krupatkin, A.I. Influence of sensory peptidergic innervation on human skin blood flow oscillations in the range 0.047–0.069 Hz. Hum Physiol 33, 296–301 (2007). https://doi.org/10.1134/S0362119707030061

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  • DOI: https://doi.org/10.1134/S0362119707030061

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