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Characteristics of ventilatory control during exercise in coronary heart disease patients

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Abstract

The relationship between the carbon dioxide ventilatory equivalent and hemodynamic parameters during exercise was studied in healthy subjects and coronary heart disease (CHD) patients. Gas exchange, ventilatory control, and central hemodynamics during graded exercise were analyzed in 85 subjects, including 32 healthy subjects and 53 CHD patients. Twenty-seven CHD patients had coronary insufficiency but not heart failure and had a left ventricle ejection fraction of ≥50%; 26 patients had chronic heart failure and an ejection fraction of <40%. A high carbon dioxide ventilatory equivalent and its disturbed response (a decrease below 20%) with an increase in physical load, which reflects an imbalance of ventilatory control with decreased parameters of maximum oxygen consumption and hemodynamics, allows the ventilatory equivalent to be used as a marker for stratifying CHD patients with chronic heart failure.

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Authors and Affiliations

  1. Institute of Psychophysiology and Rehabilitation, Kaunas Medical University, Palanga, LT-5720, Lithuania

    J. Brozhaitene & G. Žiliukas

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  1. J. Brozhaitene
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  2. G. Žiliukas
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Original Russian Text © J. Brozhaitene, G. Žiliukas, 2006, published in Fiziologiya Cheloveka, 2006, Vol. 32, No. 4, pp. 24–28.

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Brozhaitene, J., Žiliukas, G. Characteristics of ventilatory control during exercise in coronary heart disease patients. Hum Physiol 32, 394–397 (2006). https://doi.org/10.1134/S0362119706040037

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  • DOI: https://doi.org/10.1134/S0362119706040037

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