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Protein–protein interactions of huntingtin in the hippocampus

  • Structural and Functional Analysis of Biopolymers and Their Complexes
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Abstract

Huntingtin (HTT) occurs in the neuronal cytoplasm and can interact with structural elements of synapses. Huntington’s disease (HD) results from pathological expansion of a polyglutamine stretch in the HTT molecule, being probably associated with aberrant protein–protein interactions. The pathogenetic mechanism is still incompletely understood. Alterations of the synaptic structure and plasticity in the hippocampus are observed in early HD. The objective of the study was to theoretically evaluate the HTT contribution to changes in synaptic plasticity by integrating the available experimental data. HTT protein complexes are involved in maintaining the efficiency of synaptic transmission. A pathogenic HTT form (polyQ-HTT) probably disrupts the protein–protein interactions in distorts the dynamics of molecular processes in the synapsis. It was assumed that polyQ-HTT may compete with postsynaptic density proteins and proteins regulating cytoskeleton remodeling.

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Abbreviations

LTP:

long-term potentiation

AMPAR:

α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor

HD:

Huntington’s disease

CME:

clathrin-mediated endocytosis

HTT:

huntingtin

AP2:

adaptor protein 2

HIP1:

huntingtininteracting protein 1

Pacsin1:

protein kinase C and casein kinase substrate in neurons protein 1

SH3G3:

SH3 domaincontaining GRB2-like protein 3

Dyn:

dynamin

ITSN1:

intersectin 1 (EH and SH3 domain protein 1

ArhGAP31:

Rho GTPase-activating protein 31

N-Was:

neural Wiskott–Aldrich syndrome protein

Hip1R:

Huntingtin-interacting protein 1-related protein

KIF5A:

kinesin heavy chain isoform 5A

Grip1:

AMPA receptor subunit–GluR2-interacting protein

GluR2:

GluRS subunit of AMPAR

HAP1:

HTT-associated protein 1

FRMPD4:

FERM and PDZ domain-containing protein 4

S-SCAM:

membrane-associated guanylate kinase, WW and PDZ domaincontaining protein 2

SHANK:

SH3 and multiple ankyrin repeat domains protein 1 (2, 3)

SP:

spectrin α chain, non-erythrocytic 1

DLG1:

Disks large homolog 1

KL:

Kalirin

α-Pix:

Rho guanine nucleotide exchange factor 6

β-Pix:

Rho guanine nucleotide exchange factor 7

DBNL:

Drebrin-like protein

BAIAP2:

brainspecific angiogenesis inhibitor 1-associated protein 2

Eph:

endophilin A3

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Authors and Affiliations

  1. Institute of Computational Technologies, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090, Russia

    A. L. Proskura, S. O. Vechkapova, T. A. Zapara & A. S. Ratushniak

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  1. A. L. Proskura
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  2. S. O. Vechkapova
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  3. T. A. Zapara
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Original Russian Text © A.L. Proskura, S.O. Vechkapova, T.A. Zapara, A.S. Ratushniak, 2017, published in Molekulyarnaya Biologiya, 2017, Vol. 51, No. 4, pp. 734–742.

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Proskura, A.L., Vechkapova, S.O., Zapara, T.A. et al. Protein–protein interactions of huntingtin in the hippocampus. Mol Biol 51, 647–653 (2017). https://doi.org/10.1134/S002689331704015X

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