Skip to main content
SpringerLink
Log in

Stalled RNA polymerase is a target of the Mfd factor

  • Short Communications
  • Published:
Molecular Biology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Bohr V.A., Smith C.A., Okumoto D.S., Hanawalt P.C. 1985. DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall. Cell. 40, 359–369.

    Article  CAS  PubMed  Google Scholar 

  2. Mellon I., Hanawalt P.C. 1989. Induction of the Escherichia coli lactose operon selectively increases repair of its transcribed DNA strand. Nature. 342, 95–98.

    Article  CAS  PubMed  Google Scholar 

  3. Witkin E.M. 1994. Mutation frequency decline revisited. Bioessays. 16, 437–444.

    Article  CAS  PubMed  Google Scholar 

  4. Selby C.P., Sancar A. 1993. Molecular mechanism of transcription-repair coupling. Science. 260, 53–58.

    Article  CAS  PubMed  Google Scholar 

  5. Park J.S., Marr M.T., Roberts J.W. 2002. E. coli transcription-repair coupling factor (Mfd protein) rescues arrested complexes by promoting forward translocation. Cell. 109, 757–767.

    Article  CAS  PubMed  Google Scholar 

  6. Washburn R.S., Wang Y., Gottesman M.E. 2003. Role of E. coli transcription-repair coupling factor Mfd in Nun-mediated transcription termination. J. Mol. Biol. 329, 655–662.

    Article  CAS  PubMed  Google Scholar 

  7. Zalieckas J.M., Wray L.V. Jr., Ferson A.E., Fisher S.H. 1998. Transcription-repair coupling factor is involved in carbon catabolite repression of the Bacillus subtilis hut and gnt operons. Mol. Microbiol. 27, 1031–1038.

    Article  CAS  PubMed  Google Scholar 

  8. Belitsky B.R., Sonenshein A.L. 2011. Roadblock repression of transcription by Bacillus subtilis CodY. J. Mol. Biol., 411, 729–743.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Chambers A.L., Smith A.J., Savery N.J. 2003. A DNA translocation motif in the bacterial transcription-repair coupling factor, Mfd. Nucleic Acids Res. 31, 6409–6418.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Hao N., Krishna S., Ahlgren-Berg A., Cutts E.E., Shearwin K.E., Dodd I.B. 2014. Road rules for traffic on DNA-systematic analysis of transcriptional roadblocking in vivo. Nucleic Acids Res. 42, 8861–8872.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Epshtein V., Nudler E. 2003. Cooperation between RNA polymerase molecules in transcription elongation. Science. 300, 801–805.

    Article  CAS  PubMed  Google Scholar 

  12. Proshkin S., Rahmouni A.R., Mironov A., Nudler E. 2010. Cooperation between translating ribosomes and RNA polymerase in transcription elongation. Science. 328, 504–508.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Toulme F., Guerin M., Robichon N., Leng M., Rahmouni A.R. 1999. In vivo evidence for back and forth oscillations of the transcription elongation complex. EMBO J. 18, 5052–5060.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Datsenko K.A., Wanner B.L. 2000. One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc. Natl. Acad. Sci. U. S. A. 97, 6640–6645.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Katashkina Zh.I., Skorokhodova A.Yu., Zimenkov D.V., Gulevich A.Yu., Minaeva N.I., Doroshenko V.G., Biryukova I.V., Mashko S.V. 2005. Tuning the expression level of a gene located on a bacterial chromosome. Mol. Biol. (Moscow). 39 (5), 719–726.

    Article  CAS  Google Scholar 

  16. Dutta D., Shatalin K., Epshtein V., Gottesman M. E., Nudler E. 2011. Linking RNA polymerase backtracking to genome instability in E. coli. Cell. 146, 533–543.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Epshtein V., Kamarthapu V., McGary K., Svetlov V., Ueberheide B., Proshkin S., Mironov A., Nudler E. 2014. UvrD facilitates DNA repair by pulling RNA polymerase backwards. Nature. 505, 372–377.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia

    S. A. Proshkin & A. S. Mironov

Authors
  1. S. A. Proshkin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. S. Mironov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. S. Mironov.

Additional information

Original Russian Text © S.A. Proshkin, A.S. Mironov, 2016, published in Molekulyarnaya Biologiya, 2016, Vol. 50, No. 2, pp. 381–384.

UDC 577.214

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Proshkin, S.A., Mironov, A.S. Stalled RNA polymerase is a target of the Mfd factor. Mol Biol 50, 332–335 (2016). https://doi.org/10.1134/S0026893316020199

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0026893316020199

Keywords

Search

Navigation