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TWO Co(II)-BASED COORDINATION POLYMERS: STRUCTURAL INSIGHTS AND STIMULATION ACTIVITY ON OSTEOBLAST DIFFERENTIATION BY INCREASING THE WNT/β-CATENIN SIGNALING PATHWAY ACTIVATION

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Abstract

In this work, two Co(II)-based coordination polymers with the chemical formulae [CoCl(cptpy)·2H2O]n (1) and [Co2Cl2(cptpy)2(ma)H2O]n (2, Hcptpy = 4′-(4-carboxyphenyl)-2,2′:6′,2″-terpyridine, ma = melamine) are hydrothermally synthesized without or with employment of the template melamine. The as-prepared two complexes are studied via single crystal X-ray diffraction along with the elemental analysis. Furthermore, the protective ability of the compounds on the osteoblast differentiation is evaluated and the related detailed mechanism is explored. Firstly, the Western blot is used to detect the activation of the Wnt/β-catenin signaling pathway after treatment with the compounds. Next, the RT-PCR assay is used to measure the relative expression of indicators of vegf and vwf angiogenesis.

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Authors and Affiliations

  1. Department of Joint Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, P.R. China

    L. Shi

  2. Nursing Department, 986 Hospital of Air Force of PLA, Xi′an, Shaanxi, P.R. China

    J. Feng & J. Zhang

  3. Orthopaedic Operating Room, Xijing Hospital, AirForce Medical University, Xi′an, Shaanxi, P.R. China

    Q. Wang

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  1. L. Shi
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  2. J. Feng
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  3. J. Zhang
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  4. Q. Wang
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Correspondence to Q. Wang.

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Shi, L., Feng, J., Zhang, J. et al. TWO Co(II)-BASED COORDINATION POLYMERS: STRUCTURAL INSIGHTS AND STIMULATION ACTIVITY ON OSTEOBLAST DIFFERENTIATION BY INCREASING THE WNT/β-CATENIN SIGNALING PATHWAY ACTIVATION. J Struct Chem 61, 1461–1467 (2020). https://doi.org/10.1134/S0022476620090140

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  • DOI: https://doi.org/10.1134/S0022476620090140

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