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A New Zn(II) Compound: Luminescent Property and Promoting Knee Cartilage Repair by Modulating Iron Death

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Abstract

The hydrothermal reactions of bis{6-{5-methyl-1 H,7 H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one}}methane (L) and Zn(NO3)2·6H2O at 180 ℃ afforded a novel Zn(II) coordination polymer (CP), that is, {[Zn2(L)(µ2-O)2]·3H2O}n (1), which further characterized via Single crystal X-ray diffraction (SCXRD), elemental analysis (EA), powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA). Besides, this CP reveals strong luminescence that may be caused by the charge transfer within the ligand. In biological study, the new compound was evaluated for its protective effect on chondrocytes. This compound significantly up-regulated GPX4 and down-regulated HO-1 mRNA levels, thereby inhibiting iron death in chondrocytes.

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The data used to support the findings of this study are included within the article.

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Authors and Affiliations

  1. Department of Orthopaedics, Daping Hospital, Army Medical University, Chongqing, 400042, China

    Hai Wang, Hongjiu Qiu, Chuanjiang Xie & Jifeng Zhu

Authors
  1. Hai Wang
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  2. Hongjiu Qiu
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  3. Chuanjiang Xie
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  4. Jifeng Zhu
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Contributions

Hai Wang and Hongjiu Qiu synthesized and characterized the compounds; Chuanjiang Xie and Jifeng Zhu performed other experiments.

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Correspondence to Jifeng Zhu.

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Wang, H., Qiu, H., Xie, C. et al. A New Zn(II) Compound: Luminescent Property and Promoting Knee Cartilage Repair by Modulating Iron Death. J Fluoresc (2023). https://doi.org/10.1007/s10895-023-03530-7

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