Abstract
The effect of Ni2+, a T-type low-threshold calcium channel (T-VDCC) and Na+/Ca2+ exchanger (NCX) blocker, on cardiac and respiratory rhythm parameters was studied in newborn rats aged 3–16 days (P3–16). A distinct age dependence of the intensity of the arrhythmogenic effect evoked by calcium channel blockade was found. In 3-day-old rats injected with NiCl2 at a dose of 109 mg/kg (ED100), a transient atypical heart rhythm, representing the alternating periods of moderate bradycardia with a pathologically slow (up to 20–60 bpm) heart rhythm, occurs in 100% of animals. In parallel, a pronounced respiratory system dysfunction with burst breathing develops. This symptom complex occurs in 75% of 10–14-day-old rats and is completely absent in 15–16-day-old animals. Phenomenologically similar heart rhythm disorders are observed in newborn rats after NiCl2 injection, during poisoning with acetylcholinesterase inhibitors, and upon activation of the central N-cholinergic structures. The obtained data suggest that in the early period of rat postnatal ontogenesis, impaired mechanisms of calcium metabolism may play a certain role in the development of arrhythmogenic disorders.
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ACKNOWLEDGMENTS
The authors are grateful to Dr. S.M. Korotkov (IEPhB RAS) for valuable comments during preparation of the manuscript.
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The work was supported by the IEPhB Research Program 075-0152-22-00 and implemented using the IEPhB Research Resource Center.
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S.V. Kuznetsov carried out the planning, data collection and processing, writing and editing the manuscript. N.N. Kuznetsova was responsible for preparing and conducting the experiments, as well as data processing.
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Translated by A. Polyanovsky
Russian Text © The Author(s), 2022, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2022, Vol. 58, No. 5, pp. 432–448https://doi.org/10.31857/S0044452922050060.
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Kuznetsov, S.V., Kuznetsova, N.N. Effects of Ni2+ on Heart and Respiratory Rhythms in Newborn Rats. J Evol Biochem Phys 58, 1367–1380 (2022). https://doi.org/10.1134/S0022093022050088
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DOI: https://doi.org/10.1134/S0022093022050088