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Enzymatic Component of the Glutathione System in Russian and Buryat Women Depends on the Menopausal Phase

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Abstract

The study aimed to evaluate the state of the enzymatic component of the glutathione system in peri- and postmenopausal women of the Russian and Buryat ethnic groups. The study involved 86 female volunteers of Caucasian (ethnic group Russians, n = 52) and Mongoloid (ethnic group Buryats, n = 34) races aged from 45 to 60 years, with a peri- or postmenopausal status. The exclusion criteria were the use of hormone replacement therapy and antioxidant drugs, diseases of endocrine genesis, exacerbation of chronic diseases, premature early menopause, and surgical menopause. Glutathione S-transferase π concentration and glutathione reductase activity were assayed in blood serum, while glutathione peroxidase activity was assayed in erythrocyte lysates. A higher glutathione S-transferase π activity was revealed both in the peri- and postmenopausal Buryat women compared to the Russian ethnic group: 2617.47 [2249.89; 3270.49] ng/mL vs. 2025.73 [1457.93; 2818.66] ng/mL, respectively, in perimenopause (p = 0.034), and 2815.92 [2235.68; 3065.02] ng/mL vs. 1931.75 [1468.17; 2932.54] ng/mL, respectively, in postmenopause (p = 0.032). Between the menopausal phases, a higher glutathione reductase activity was found in postmenopausal vs. perimenopausal Russian women: 83.9 [74.6; 90.7] U/L vs. 75.5 [67.5; 80.2] U/L, respectively (p = 0.035). Thus, the enzymatic component of the glutathione system in menopausal women shows ethnospecificity toward glutathione S-transferase π and glutathione reductase.

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Funding

The study was implemented within the scheduled research program of the SCFHHR (121022500180-6) using the equipment of the Collective Research Center “Center for the Development of Progressive Personalized Technologies for Health” (SCFHHR, Irkutsk).

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Authors and Affiliations

  1. Scientific Сenter for Family Health and Human Reproduction Problems, Irkutsk, Russia

    N. V. Semenova, A. S. Brichagina, I. M. Madaeva & L. I. Kolesnikova

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  1. N. V. Semenova
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  2. A. S. Brichagina
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  3. I. M. Madaeva
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  4. L. I. Kolesnikova
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Contributions

Conceptualization and experimental design (N.V.S., L.I.K.); data collection (N.V.S., I.M.M.); data processing (N.V.S., A.S.B.); writing and editing the manuscript (N.V.S., I.M.M.); ultimate approval of the manuscript (L.I.K.).

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Correspondence to N. V. Semenova.

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Translated by A. Polyanovsky

Russian Text © The Author(s), 2022, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2022, Vol. 58, No. 4, pp. 284–290https://doi.org/10.31857/S004445292204009X.

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Semenova, N.V., Brichagina, A.S., Madaeva, I.M. et al. Enzymatic Component of the Glutathione System in Russian and Buryat Women Depends on the Menopausal Phase. J Evol Biochem Phys 58, 971–978 (2022). https://doi.org/10.1134/S0022093022040032

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