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Long-Term Ethanol Alcoholization Decreases Levodopa- Induced Aggressive Behavior in Rats

  • Comparative and Ontogenic Physiology
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Abstract

One of the old but still unsolved problems in psychiatry is the treatment of patients with a dual diagnosis of schizophrenia and alcoholism. Numerous clinical studies failed to explain unambiguously the mechanisms of formation of these comorbid disorders. Experimental modeling of dual disorders was carried out using a model of schizophrenia based on the impaired development and dopamine hypothesis of schizophrenia. To model comorbid experimental schizophrenia and alcohol abuse, the dopamine precursors, Levodopa/Carbidopa (LC), were used in combination with 15% ethanol. The aim of this study was to investigate social behavior of rats receiving LC and exposed to intermittent semi-compulsory alcoholization. After three months of the experiment, there were significantly more interactions (including aggressive–attacks, fights, bites) and submissive postures in the group of rats that received LC. Combined LC/ethanol administration did not alter rat social behavior in contrast to ethanol administered alone.

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Authors and Affiliations

  1. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia

    E. O. Kutcher, A. Yu. Egorov, N. A. Chernikova & E. V. Filatova

  2. St. Petersburg State University, St. Petersburg, Russia

    E. O. Kutcher & A. Yu. Egorov

Authors
  1. E. O. Kutcher
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  2. A. Yu. Egorov
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  3. N. A. Chernikova
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  4. E. V. Filatova
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Corresponding author

Correspondence to E. O. Kutcher.

Additional information

Original Russian Text © E.O. Kutcher, A.Yu. Egorov, N.A. Chernikova, E.V. Filatova, 2018, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2018, Vol. 54, No. 3, pp. 189–193.

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Kutcher, E.O., Egorov, A.Y., Chernikova, N.A. et al. Long-Term Ethanol Alcoholization Decreases Levodopa- Induced Aggressive Behavior in Rats. J Evol Biochem Phys 54, 216–220 (2018). https://doi.org/10.1134/S0022093018030067

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  • DOI: https://doi.org/10.1134/S0022093018030067

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