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Study of protective effects of exogenous heat shock protein 70 kDa in model of sleep deprivation in pigeon Columba livia

  • Comparative and Ontogenic Physiology
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Abstract

Electroencephalographic methods were used to study effects of preparation of the exogenous heat shock protein with molecular mass of 70 kDa (Hsp70i/Hsc70) on time characteristics of sleep and wakefulness, brain temperature, peripheral vasomotor reactions, and thoracic muscle contractile activity after the 5-hour forceful sleep deprivation in the pigeon Columba livia. Administration of Hsp70i/Hsc70 into the third brain ventricle at once after the end of sleep deprivation eliminated disturbances in the sleep-wakefulness cycle organization and decreased the thoracic muscle contractile activity and the brain temperature as early as for the first hour of postdeprivation period. For the subsequent hours, the Hsp70i/Hsc70 action was characterized by an increase of the total time of deep sleep and a decrease of the total time of the rapid eye movement sleep. We suggest that the protective effects of the exogenous Hsp70i/Hsc70 preparation are associated with its ability to decrease activity of the hypothalamo-pituitary-adrenal axis and to enhance the stress-limiting function of the slow eye movement sleep.

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Authors and Affiliations

  1. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia

    K. V. Lapshina & I. V. Ekimova

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  1. K. V. Lapshina
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  2. I. V. Ekimova
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Original Russian Text © K. V. Lapshina, I. V. Ekimova, 2010, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2010, Vol. 46, No. 5, pp. 387–394.

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Lapshina, K.V., Ekimova, I.V. Study of protective effects of exogenous heat shock protein 70 kDa in model of sleep deprivation in pigeon Columba livia . J Evol Biochem Phys 46, 461–470 (2010). https://doi.org/10.1134/S0022093010050051

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