Abstract
There was performed a comparative analysis of phospholipids and of lipid physicochemical characteristics in spleen, blood erythrocytes, and liver of the root voles caught in the natural environmental habitation at different phases of the population cycle, as well of the animals born and raised throughout the entire live in vivarium, depending on the animals’ sex and age. The age-related changes in the phospholipid composition have been established to correlate with lipid physicochemical characteristics, while the scale and direction of the changes depend on the tissue functional role, the initial level of the antioxidative activity (AOA) of its lipids, and sex of the animals. In the process of the organism aging, parameters of the system of regulation of lipid peroxidation change not unidirectionally; in group of animals of the same age, individuals with different biochemical characteristics can be present. Under natural conditions of habitation the degree of expression of age-related changes is modified by populational factors.
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Vladimirov, Yu.A. and Archakov, A.I., Perekisnoe okislenie lipidov v biologicheskikh membranakh (Lipid Peroxidation in Biological Membranes), Moscow, 1972.
Burlakova, E.B., Alesenko, A.V., Molochkina, E.M., et al., Bioantioksidanty v luchevom porazhenii i zlokachestvennom roste (Bioantioxidants in Radiation Damage and Malignant Growth), Moscow, 1975.
Frankel, E.N., Secondary Products of Lipid Oxidation, Chem. Physics Lipids, 1987, vol. 44, pp. 73–85.
Membrane Lipid Oxidation, Vigo-Perfley, C., Ed., Boca Raton, Ann Arbor, Boston, 1991, vol. 3.
Hensley, K., Robinson, K.A., Gabbita, S.P., Salsman, S., and Floyd, R.A., Reactive Oxygen Species, Cell Signaling, and Cell Injury, Free Radic. Biol. Med., 2000, vol. 28, pp. 1456–1462.
Kreps, E.M., Lipidy kletochnykh membran (Lipids of Cell Membranes), Leningrad, 1981.
Klimov, A.N. and Nikulcheva, N.G., Lipidy, lipoproteiny i ateroskleroz (Lipids, Lipoproteins, and Atherosclerosis), St. Petersburg, 1995.
Goni, F.M. and Alonso, A., Structure and Function Properties of Diacyl-Glycerols in Membranes, Prog. Lipid Res., 1999, vol. 38, pp. 1–48.
Burlakova, Ye.B., Palmina, N.P., and Maltseva, Ye.L., A Physicochemical System Regulating Lipid Peroxidation in Biomembranes during Tumor Growth, Membrane Lipids, Vigo-Pelfrei, C., Ed., Boca Raton, Ann Arbor, Boston, 1991, vol. 3, pp. 209–237.
Shishkina, L.N., Peculiarities of Functioning of Physicochemical System of Regulation of Lipids Peroxidation in Biological Objects of Different Degree of Complexity in Norm and under Action of Damaging Factors, Doctorate Dissertation, Moscow, 2003.
Menshikova, M.G. and Varfolomeeva, A.T., Oxidative Stress in Inflammation, Usp. Sovr. Biol., 1997, vol. 117, pp. 155–171.
Sergeeva, M.G. and Varfolomeeva, A.T., Kaskad arakhidonovoi kisloty (Cascade of Arachidonic Acid), Moscow, 2006.
Burlakova, E.B. and Khrapova, N.G., Membrane Lipid Peroxidation and Natural Antioxidants, Usp. Khimii, 1985, vol. 54, pp. 1540–1558.
Burlakova, E.B., Molochkina, E.M., Palmina, N.P., and Slepukhina, L.V., A Change of Antioxidant Activity of Lipids at Aging, Vopr. Med. Khim., 1976, vol. 22, pp. 541–546.
Emanuel, N.M., Antioxidants in Life Prolongation, Biologiya stareniya (Biology of Aging), Leningrad, 1982, pp. 569–586.
Todorov, I.N. and Todorov, G.I., Stress, starenie i ikh biokhimicheskaya korrektsiya (Stress, Aging, and their Biochemical Correction), Moscow, 2003.
Obukhova, L.K., Izmailov, D.M., and Solovieva, A.S., Academician N.M. Emanuel and Development of Principles of Control of the Process of Living Organisms’ Aging, Khimicheskaya i biologichesakaya kinetika. Novye gorizonty (Che mical and Biological Kinetics. New Horizons), vol. 2. Biological Kinetics, Moscow, 2005, pp. 471–495.
Vladimirov, Yu.A., Proskurina, E.V., Izmailov, D.Yu., Novikov, A.A., Brusnichkin, A.V., Osipov, A.N., and Kagan, V.E., Mechanism of Activation of Peroxidase Activity of Cytochtome c by Cardiolipin, Biokhimiya, 2006, vol. 71, pp. 1215–1224.
Skulachev, V.P., An Attempt of Biochemists to Attack the Aging Problem: “Megaproject” on Penetrating Ions. First Results and Perspectives, Biokhimiya, 2007, vol. 72, pp. 1700–1714.
Keits, M., Tekhnika lipidologii (Lipidology Technique), Moscow, 1975.
Biologicheskie membrany. Metody (Biological Membranes. Methods), Findley, G.B. and Evance, U.G., Eds., Moscow, 1990.
Shevchenko, O.G., Shishkina, L.N., and Kudyasheva, A.G., Composition of Phospholipids in Tissues of Root Voles Microtus oeconomus Inhabiting Territories with Increased Radiation Background, Zh. Evol. Biokhim. Fiziol., 2006, vol. 42, pp. 218–224.
Shishkina, L.N. and Khrustova, N.V., Kinetic Characteristics of Lipids of Mammalian Tissues in Autooxidation Reactions, Biofizika, 2006, vol. 51, pp. 340–346.
Menshov, V.A., Shishkina, L.N., and Kishkovskii, Z.N., Methyloleate Model in Study of the Mechanism of Regulatory Interactions of Lipids of Natural Sorbents and Environment, Prikl. Biokhim. Mikrobiol., 1994, vol. 30, pp. 632–640.
Brin, E.F. and Travin, S.O., Modeling of Mechanisms of Chemical Reactions, Khim. Fizika, 1991, vol. 10, pp. 830–837.
Shevchenko, O.G., Shishkina, L.N., and Kudyasheva, A.G., Effect of Population Factors on Composition of Phospholipids from Various Tissues of the Root Vole of Natural Populations, Zh. Evol. Biokhim. Fiziol., 2002, vol. 38, pp. 131–135.
Kudyasheva, A.G., Shishkina, L.N., Shevchenko, O.G., Bashlykova, L.N., and Zagorskaya, N.G., Biological Consequences of Increased Natural Radiation Background for Microtus oeconomus Pall. Population, J. Environ. Radioact., 2007, vol. 97, pp. 30–41.
Kudyasheva, A.G., Shishkina, L.N., Zagorskaya, N.G., and Taskaev, A.I., Biokhimicheskie mekhanizmy radiatsionnogo porazheniya prirodnykh populyatsii myshevidnykh gryzunov (Biochemical Mechanisms of Radiation Damages of Natural Populations of Mouse-Like Rodents), St. Petersburg, 1997.
Kudyasheva, A.G., Shishkina, L.N., Shevchenko, O.G., Bashlykova, L.A., and Zagorskaya, N.G., Biologicheskie effekty radiatsionnogo zagryazneniya v populyatsiyakh mychevidnykh gryzunov (Biological Effects of Radiation Contamination in Populations of Mouse-Like Rodents), Ekaterinburg, 2004.
Menshov, V.A. and Shishkina, L.N., Effect of Hydrophobicity of the Yeast Cell Walls on the Rate of Reaction of Methyloleate Autooxidation, Biofizika, 2006, vol. 51, pp. 491–498.
Khrustova, N.V. and Shishkina, L.N., Role of Peroxides in the Mechanism of Low-Temperature Methyloleate Autooxidation and of Its Solutions with Lipids, Kinet. Kataliz, 2004, vol. 45, pp. 848–858.
Kozlov, M.V., Urnysheva, V.V., and Shishkina, L.N., Interconnection of Parameters of the Lipid Peroxidation Regulatory System and Morphological Factors of Mouse Liver, Zh. Evol. Biokhim. Fiziol., 2008, vol. 44, pp. 398–402.
Mileykovskaya, E., Jang, M., and Doukhan, V., Role of Cardiolipin in Energy-Storing Membranes, Biokhimiya, 2005, vol. 70, pp. 191–196.
Todorov, I.N., Mitochondria: Oxidative Stress, Mutation of Mitochondrial DNA, Pathologies, Aging, and Apoptosis, Khimicheskaya i biologicheskaya kinetika. Novye gorizonty (Chemical and Biological Kinetics. New Horizons), vol. 2. Biological Kinetics, Moscow, 2005, pp. 513–571.
Brokerkhof, Ch. and Gensen, R., Lipoliticheskie fermenty (Lipolytic Enzymes), Moscow, 1978.
Roelofsen, B., Membrane Proteins, 11th FEBS Meething, vol. 45, Copenhagen, 1978, p. 183.
Gennis, R., Biomembrany: Molekulyarnaya struktura i funktsii (Biomembranes: Molecular Structure and Functions), Moscow, 1997.
Dyatlovitskaya, E.V., Sphingolipids and Tumor Growth, Biokhimiya, 1995, vol. 60, pp. 843–850.
Rodi, P.M., Cabeza, M.S., and Gennaro, A.M., Detergent Solubilization of Bovine Eryhrocytes. Comparison between the Insoluble Material and the Intact Membrane, Biophys. Chem., 2006, vol. 122, pp. 114–122.
Novistkii, V.V., Ryazantseva, N.V., and Stepovaya, E.A., Fiziologiya i patofiziologiya eritrotsita (Physiology and Pathophysiology of Erythrocyte), Tomsk, 2004.
Shishkina, L.N., Smotryaeva, M.A., Klimovich, M.A., Kozlov, M.V., and Urnysheva, V.V., Change of the State of Lipid Peroxidation System in Tissues of Rodents of Different Species during Aging, Usp. Gerontol., 2008, vol. 21, pp. 513–515.
Gichev, Yu.P., Pechen’: adaptatsiya, ekologiya (Liver: Adaptation, Ecology), Novosibirsk, 1993.
Avrova, N.F., Biochemical Mechanisms of Adaptation to Changing Environmental Conditions in Vertebrates: Role of Lipids, Zh. Evol. Biokhim. Fiziol., 1999, vol. 35, pp. 170–180.
Smirnov, L.P. and Bogdan, V.V., Lipidy in fiziologobiokhimicheskikh adaptatsiyakh ektotermnykh organizmov k abioticheskim i bioticheskim faktoram sredy (Lipids in Physiologo-Biochemical Adaptations of Ectothermal Organisms to Abiotic and Biotic Environmental Factors), Moscow, 2007.
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Original Russian Text © O. G. Shevchenko, N. G. Zagorskaya, L. N. Shishkina, 2010, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2010, Vol. 46, No. 4, pp. 297–303.
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Shevchenko, O.G., Zagorskaya, N.G. & Shishkina, L.N. Correlation of phospholipid composition and physicochemical characteristics of lipids in tissues of the root vole Microtus oeconomus of different ages. J Evol Biochem Phys 46, 357–365 (2010). https://doi.org/10.1134/S0022093010040046
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DOI: https://doi.org/10.1134/S0022093010040046