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Synthesis of Substituted Octacalcium Phosphate for Filling Composite Implants Based on Polymer Hydrogels Produced by Stereolithographic 3D Printing

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Abstract

Based on theoretical and experimental analysis of ionic equilibria in buffer solutions, we have found conditions for octacalcium phosphate (OCP), Ca8(HPO4)2(PO4)4 ∙ 5H2O, synthesis. Succinate-substituted OCP, Ca8(HPO4)2–хSucx(PO4)4 ∙ 5H2O, with x = 0.8–0.9 has been synthesized at pH 5.5 and t = 60°C in 3 h via α-TCP hydrolysis in a 0.25 M succinic buffer solution. The synthesis product is more stable to thermolysis than is pure OCP: the apatite-like product is stable up to 630°C. The succinate@OCP powder has been used as a filler for poly(ethylene glycol)diacrylate-based hydrogel in producing a composite implant by stereolithographic 3D printing.

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Authors and Affiliations

  1. Faculty of Materials Science, Moscow State University, Vorob’evy gory 1/73, Moscow, 119991, Russia

    A. A. Tikhonov, E. V. Kukueva, P. V. Evdokimov, E. S. Klimashina & V. I. Putlyaev

  2. Kurchatov Institute National Research Centre, pl. Akademika Kurchatova 1, Moscow, 123182, Russia

    E. V. Kukueva

  3. Faculty of Chemistry, Moscow State University, Vorob’evy gory 1/3, Moscow, 119991, Russia

    P. V. Evdokimov, E. S. Klimashina & V. I. Putlyaev

  4. Faculty of Fundamental Medicine, Moscow State University, Lomonosovskii pr. 27/1, Moscow, 119192, Russia

    I. M. Shcherbakov & V. E. Dubrov

Authors
  1. A. A. Tikhonov
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  2. E. V. Kukueva
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  3. P. V. Evdokimov
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  4. E. S. Klimashina
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  5. V. I. Putlyaev
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  6. I. M. Shcherbakov
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  7. V. E. Dubrov
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Correspondence to V. I. Putlyaev.

Additional information

Original Russian Text © A.A. Tikhonov, E.V. Kukueva, P.V. Evdokimov, E.S. Klimashina, V.I. Putlyaev, I.M. Shcherbakov, V.E. Dubrov, 2018, published in Neorganicheskie Materialy, 2018, Vol. 54, No. 10, pp. 1123–1132.

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Tikhonov, A.A., Kukueva, E.V., Evdokimov, P.V. et al. Synthesis of Substituted Octacalcium Phosphate for Filling Composite Implants Based on Polymer Hydrogels Produced by Stereolithographic 3D Printing. Inorg Mater 54, 1062–1070 (2018). https://doi.org/10.1134/S0020168518100175

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  • DOI: https://doi.org/10.1134/S0020168518100175

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