Abstract
The paramagnetic properties of compounds resulting from the synthesis of nanohydroxyapatite in the presence of Fe(III) ions have been studied by electron paramagnetic resonance, Mössbauer spectroscopy, and magnetochemistry. Based on the obtained results on the mechanism of the reaction between an orthophosphoric acid solution and an aqueous calcium hydroxide suspension, we have found conditions for incorporating Fe(III) impurity ions into hydroxyapatite. We have studied samples differing in the sequence in which reagents were mixed and in hydroxyapatite crystallite formation conditions. It has been shown that, in all instances, the composition and properties of the iron-containing phases in the composites depend significantly on both synthesis and heat treatment conditions.
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Gupta, A.K. and Gupta, M., Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications, Biomaterials, 2005, vol. 26, pp. 3995–4021.
Salata, O.V., Applications of nanoparticles in biology and medicine, J. Nanobiotechnol., 2004, vol. 2, no. 3, pp. 1–6.
Albanese, A., Tang, P.S., and Chan, W.S., The effect of nanoparticle size, shape, and surface chemistry on biological systems, Annu. Rev. Biomed. Eng., 2012, vol. 14, pp. 1–16.
Kuzmann, E., Garg, V.K., Oliveira, A.C., et al., Mössbauer study of the effect of pH on Fe valence in ironpolygalacturonate as a medicine for human anaemia, Radiat. Phys. Chem., 2015, vol. 107, pp. 195–198.
Kaushik, A., Jayant, R.D., Sagar, V., and Nair, M., The potential of magneto-electric nanocarriers for drug delivery, Expert. Opin. Drug. Delivery, 2014, vol. 11, no. 10, pp. 1635–1646.
Dash, N.A., Ghosal, P.M., Mahipal, Y.K., et al., The use of magnetite nanoparticles in applied medicine, J. Mech. Eng. Res. Devel., 2014, vol. 37, pp. 15–18.
Veiseh, O., Gunn, J.W., and Zhang, M., Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging, Adv. Drug. Deliv. Rev., 2010, vol. 63, pp. 284–304.
Chomouckaa, J., Drbohlavovaa, J., Huskab, D., et al., Magnetic nanoparticles and targeted drug delivering, Pharmacol. Res., 2010, vol. 62, pp. 144–149.
Mahmoudi, M., Sant, S., Wang, B., et al., Superparamagnetic iron oxide nanoparticles (SPIONs): development, surface modification and applications in chemotherapy, Adv. Drug. Deliv. Rev., 2011, vol. 63, pp. 24–46.
Hergt, R., Dutz, S., Muller, R., and Zeisberger, M., Magnetic particle hyperthermia: nanoparticle magnetism and materials development for cancer therapy, J. Phys. Condens. Matter, 2006, vol. 18, no. 38, pp. 2919–2934.
Hergt, R., Dutz, S., and Roder, M., Effects of size distribution on hysteresis losses of magnetic nanoparticles for hyperthermia, J. Phys. Condens. Matter, 2008, vol. 20, no. 38, pp. 385214–385226.
Laurent, S., Dutz, S., Häfeli, U.O., and Mahmoudi, M., Magnetic fluid hyperthermia: focus on superparamagnetic iron oxide nanoparticles, Adv. Colloid Interface Sci., 2011, vol. 166, pp. 8–23.
Cuny, L., Pia, M., Gisela, H., et al., Magnetic resonance imaging reveals detailed spatial and temporal distribution of iron-based nanoparticles transported through water-saturated porous media, J. Contam. Hydrol., 2015, vol. 182, pp. 51–62.
Szpak, A., Kania, G., Skórka, T., et al., Stable aqueous dispersion of superparamagnetic iron oxide nanoparticles protected by charged chitosan derivatives, J. Nanopart. Res., 2013, vol. 15, pp. 1372–1383.
Polikarpov, D., Cherepanov, V., Chuev, M., et al., Mossbauer evidence of 57Fe3O4 based ferrofluid biodegradation in the brain, Hyperfine Interact., 2014, vol. 226, pp. 421–430.
Li, W.J., Zhou, X.L., Liu, B.L., et al., The effect of nanoparticle on vitrification of porcine GV-stage oocytes, Chin. J. Biomed. Eng., 2013, vol. 32, no. 5, pp. 601–605.
Shimizu, T., Akahane, M., Ueha, T., et al., Osteogenesis of cryopreserved osteogenic matrix cell sheets, Cryobiology, 2013, vol. 66, no. 3, pp. 326–332.
Xing, Z., Zhang, J., Kong, L., et al., Combination of cryopreserved hydroxyapatite/bone marrow mesenchymal stem cells repairs rabbit radial defects, Chin. J. Tiss. Eng. Res., 2013, vol. 17, no. 25, pp. 4629–4636.
Fuller, B.J., Cryoprotectants: the essential antifreezes to protect life in the frozen state, CryoLetters, 2004, vol. 25, no. 6, pp. 375–388.
Laurent, S., Forge, D., Port, M., et al., Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications, Chem. Rev., 2008, vol. 108, no. 6, pp. 2064–2110.
Nel, A.E., Mädler, L., Velegol, D., et al., Understanding biophysicochemical interactions at the nano–bio interface, Nat. Mater., 2009, vol. 8, pp. 543–557.
Jarupoom, P. and Jaita, P., Influence of barium hexaferrite on magnetic properties of hydroxyapatite ceramics, J. Nanosci. Nanotechnol., 2015, vol. 15, pp. 9217–9221.
Pankaew, P. and Klumdoung, P., Structural and magnetic characterizations of nano sized grain zinc ferrite/hydroxyapatite ceramic prepared by solid state reaction route, J. Nanosci. Nanotechnol., 2015, vol. 15, pp. 9281–9286.
Webster, T.J., Massa-Schlueter, E.A., Smith, J.L., and Slamovich, E.B., Osteoblast response to hydroxyapatite doped with divalent and trivalent cations, Biomaterials, 2004, vol. 25, pp. 2111–2121.
Hou, C.H., Hou, S.M., Hsueh, Y.S., et al., The in vivo performance of biomagnetic hydroxyapatite nanoparticles in cancer hyperthermia therapy, Biomaterials, 2009, vol. 30, pp. 3956–3960.
Dorozhkin, S.V. and Epple, M., Biological and medical significance of calcium phosphates, Angew. Chem., Int. Ed. Engl., 2002, vol. 41, no. 17, pp. 3130–3146.
Vallet-Regí, M., Evolution of bioceramics within the field of biomaterials, C. R. Chim., 2010, vol. 13, nos. 1–2, pp. 174–185.
Dorozhkin, S.V., Bioceramics of calcium orthophosphates, Biomaterials, 2010, vol. 31, pp. 1465–1485.
Severin, A.V. and Pankratov, D.A., Synthesis of nanohydroxyapatite in the presence of iron(III) ions, Russ. J. Inorg. Chem., 2016, vol. 61, no. 3, pp. 265–272.
Melikhov, I.V., Komarov, V.F., Severin, A.V., et al., Two-dimensional crystalline hydroxyapatite, Dokl. Phys. Chem., 2000, vol. 373, no. 3, pp. 355–358.
Liao, C.J., Lin, F.H., Chen, K.S., and Sun, J.S., Thermal decomposition and reconstitution of hydroxyapatite in air atmosphere, Biomaterials, 1999, vol. 20, pp. 1807–1813.
Komozin, P.N., Pankratov, D.A., and Kiselev, Yu.M., EPR spectra of solutions of platinum superoxo hydroxo complexes, Russ. J. Inorg. Chem., 1999, vol. 44, no. 12, pp. 1945–1951.
Jiang, M., Terra, J., Rossi, A.M., et al., Fe2+/Fe3+ substitution in hydroxyapatite: theory and experiment, Phys. Rev. B: Condens. Matter Mater. Phys., 2002, vol. 66, pp. 22410710–22410715.
Koksharov, Yu.A., Gubin, S.P., Kosobudsky, I.D., et al., Electron paramagnetic resonance spectra near the spin-glass transition in iron oxide nanoparticles, Phys. Rev. B: Condens. Matter Mater. Phys., 2001, vol. 63, pp. 124071–124074.
Carbone, C., Benedetto, F.Di., Marescotti, P., et al., Natural Fe-oxide and oxyhydroxide nanoparticles: an EPR and SQUID investigation, Mineral. Petrol., 2005, vol. 85, pp. 19–32.
Koksharov, Yu.A., Dolzhenko, V.D., and Agazade, S.A., Electron magnetic resonance of synthetic goethite in the range of the magnetic transition, Phys. Solid State, 2010, vol. 52, no. 9, pp. 1929–1934.
Koksharov, Yu.A., Pankratov, D.A., Gubin, S.P., et al., Electron paramagnetic resonance of ferrite nanoparticles, J. Appl. Phys., 2001, vol. 89, no. 4, pp. 2293–2298.
Singh, R.K., Kothiyal, G.P., and Srinivasan, A., Electron spin resonance and magnetic studies on CaO–SiO2–P2O5–Na2O–Fe2O3 glasses, J. Non-Cryst. Solids, 2008, vol. 354, pp. 3166–3170.
Pankratov, D.A., Mössbauer study of oxo derivatives of iron in the Fe2O3–Na2O2 system, Inorg. Mater., 2014, vol. 50, no. 1, pp. 82–89.
Sorkina, T.A., Polyakov, A.Yu., Kulikova, N.A., et al., Nature-inspired soluble iron-rich humic compounds: new look at the structure and properties, J. Soils Sediments, 2014, vol. 14, no. 2, pp. 261–268.
Dyar, M.D., Jawin, E.R., Breves, E., et al., Mössbauer parameters of iron in phosphate minerals: implications for interpretation of martian data, Am. Mineral., 2014, vol. 99, nos. 5–6, pp. 914–942.
Mingzhi, J., Xianhao, C., Weiming, X., et al., Mossbauer study of ferric phosphate catalysts, Hyperfine Interact., 1988, vol. 41, pp. 645–648.
Polyakov, A.Yu., Goldt, A.E., Sorkina, T.A., et al., Constrained growth of anisotropic magnetic d-FeOOH nanoparticles in the presence of humic substances, CrystEngComm, 2012, vol. 14, no. 23, pp. 8097–8102.
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Original Russian Text © D.A. Pankratov, V.D. Dolzhenko, E.A. Ovchenkov, M.M. Anuchina, A.V. Severin, 2017, published in Neorganicheskie Materialy, 2017, Vol. 53, No. 1, pp. 94–104.
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Pankratov, D.A., Dolzhenko, V.D., Ovchenkov, E.A. et al. Properties of iron-containing nanohydroxyapatite-based composites. Inorg Mater 53, 115–124 (2017). https://doi.org/10.1134/S0020168517010125
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DOI: https://doi.org/10.1134/S0020168517010125