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Spectral–Luminescent and Spectrophotometric Study of Molecular and Anionic Forms of N-Methyl Derivatives of 5-Fluorouracil in Aqueous Solutions

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Abstract

Spectrophotometric and fluorescent (FL) methods have been used to study solutions of N-methyl derivatives of 5-fluorouracil (FU): 1-methyl-5-fluorouracil (1M-FU), 3-methyl-5-fluorouracil (3M-FU), and 1,3-dimethyl-5-fluorouracil (1,3DM-FU) in neutral (pH 6.8) and alkaline (pH 11) aqueous media. Fluorescence parameters, such as FL spectrum and quantum yield (φ), of 1M-FU, 3M-FU, 1,3DM-FU, and their anionic forms were recorded for the first time. Bathofluoric shifts in the FL maxima and an increase in the FL quantum yields of these compounds compared to unsubstituted FU at pH 6.8 and pH 11 have been observed. Interpretation of the revealed features is presented.

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ACKNOWLEDGMENTS

Spectral-luminescence measurements were performed using the equipment of the “Khimiya” Shared-Use Center at the Ufa Institute of Chemistry of the Ural Federal Research Center and the “Agidel” Republican Shared- Use Center at the Ural Federal Research Center of the Russian Academy of Sciences.

Funding

The work was carried out within the framework of the State Assignment on the topics of research at the Ural Institute of Chemistry of the Ural Federal Research Center of the Russian Academy of Sciences: “Mechanism and kinetic patterns of oxidative transformations involving highly active intermediates in chemical and biochemical processes” and “Establishment of the structure, composition and physicochemical properties of organic, bioorganic, polymeric molecules and coordination compounds by methods of chromatography, mass spectrometry, IR, UV, EPR and NMR spectroscopy.”

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Authors and Affiliations

  1. Ufa Institute of Chemistry, Ural Federal Research Center, Russian Academy of Sciences, 450054, Ufa, Russia

    S. S. Ostakhov, G. S. Abdrakhimova, R. R. Kayumova, S. P. Ivanov & S. L. Khursan

Authors
  1. S. S. Ostakhov
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  2. G. S. Abdrakhimova
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  3. R. R. Kayumova
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  4. S. P. Ivanov
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  5. S. L. Khursan
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Corresponding author

Correspondence to S. S. Ostakhov.

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The authors declare that they have no conflicts of interest.

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Translated by S. Zatonsky

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Ostakhov, S.S., Abdrakhimova, G.S., Kayumova, R.R. et al. Spectral–Luminescent and Spectrophotometric Study of Molecular and Anionic Forms of N-Methyl Derivatives of 5-Fluorouracil in Aqueous Solutions. High Energy Chem 56, 158–162 (2022). https://doi.org/10.1134/S0018143922030080

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  • DOI: https://doi.org/10.1134/S0018143922030080

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