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Synthesis, Characterization, and Biological Evaluation of New Cyclic Quinazoline Derivatives as Potential Antibacterial and Antifungal Agents

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Abstract

Heterocyclic compounds are crucial for medicinal chemistry and the development of therapeutic agents like broad-spectrum antibiotics. This study devised a facile procedure to synthesize novel antimicrobial bicyclic heterocycles from 2-mercapto-3-phenylquinazolin-4(3H)-one. Advanced analytical techniques including 1H and 13C NMR, elemental analysis, and FT-IR spectroscopy characterized the intricate chemical structures of the products. In vitro assays tested the heterocycles against aerobic and anaerobic bacterial strains using fluconazole and ciprofloxacin as antifungal and antibacterial controls. Results demonstrated the formidable broad-spectrum antibacterial and antifungal activities of the synthesized compounds, with growth inhibition approaching that of the positive controls. These findings highlight the immense potential of these novel heterocyclic compounds as antimicrobial agents. Further research can optimize their drug-like properties for eventual clinical use in combating drug-resistant infections.

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This work was supported by ongoing institutional funding. No additional grants to carry out or direct this particular research were obtained.

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Authors and Affiliations

  1. Department of Chemistry, College of Sciences, University of Baghdad, 10071, Baghdad, Iraq

    Oday H. R. Al-Jeilawi, Safaa H. F. Tuama, Iftikhar A. Hussein & Andy N. S. Shamaya

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  1. Oday H. R. Al-Jeilawi
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  2. Safaa H. F. Tuama
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Correspondence to Oday H. R. Al-Jeilawi.

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Al-Jeilawi, O.H., Tuama, S.H., Hussein, I.A. et al. Synthesis, Characterization, and Biological Evaluation of New Cyclic Quinazoline Derivatives as Potential Antibacterial and Antifungal Agents. Dokl Chem 514, 27–34 (2024). https://doi.org/10.1134/S0012500823600554

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