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Analysis of Oscillatory Processes in the Cardiovascular System in Response to Local Heating in Patients with Type 2 Diabetes Mellitus

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Abstract

A comprehensive spectral analysis of heart rate variability and skin perfusion of the extremities in patients with type 2 diabetes mellitus in response to local heating and identification of significant predictors of pathophysiological changes in the cardiovascular system has been carried out. Electrocardiogram and skin perfusion on the forearm and foot were measured by laser Doppler flowmetry at rest and under local heating in healthy individuals and diabetic patients. The signals of laser Doppler flowmetry and heart rate variability (according to electrocardiographic data) were subjected to wavelet analysis. Receiver operating characteristic analysis was used to evaluate significant predictors. It was found that in patients, compared with healthy individuals, there was (1) a decrease in the reserve of cutaneous blood flow on the foot under heating, (2) a decrease in the amplitudes of heart rate oscillations at rest and under heating, (3) an increase in the amplitudes of oscillations of laser Doppler flowmetry signals on the forearm in respiratory intervals and cardiac intervals at rest and under heating, and (4) a decrease in the amplitudes of oscillations of laser Doppler flowmetry signals on the foot in the myogenic interval at rest and in the cardiac interval under heating. The parameters of the cardiovascular system (the energy of heart rate variability in the low frequency interval and oscillations of laser Doppler flowmetry signals on the forearm in respiratory interval, which can serve as markers for early diagnosis of microvascular disorders) with high discriminatory power to distinguish patients and healthy individuals in response to local heating were revealed.

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ACKNOWLEDGMENTS

The authors thank all participants of the study (healthy volunteers and patients).

Funding

The work was supported by the Russian Science Foundation, project no. 22-15-00215.

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Authors and Affiliations

  1. Institute of Cell Biophysics, Russian Academy of Sciences, 142290, Pushchino, Moscow oblast, Russia

    I. V. Tikhonova, A. V. Tankanag & A. A. Grinevich

  2. Hospital of Pushchino Scientific Center, Russian Academy of Sciences, 142290, Pushchino, Moscow oblast, Russia

    I. E. Guseva

Authors
  1. I. V. Tikhonova
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  2. A. V. Tankanag
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  3. I. E. Guseva
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  4. A. A. Grinevich
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Corresponding author

Correspondence to A. A. Grinevich.

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CONFLICT OF INTEREST

The authors of this work declare that they have no conflicts of interest.

ETHICS APPROVAL AND CONSENT TO PARTICIPATE

The study was conducted in accordance with the principles of the Helsinki Declaration of the World Medical Association (2013) and the protocol of the Local Ethics Committee of the Hospital of the Pushchino Scientific Center of the Russian Academy of Sciences no. 2 dated October 4, 2014. All subjects gave voluntary written informed consent to participate in the study after receiving explanations about the potential risks and benefits, as well as the nature of the upcoming study.

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Translated by E. Puchkov

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Abbreviations: DM2T, type 2 diabetes mellitus; CVS, cardiovascular system; HRV, heart rate variability; ECG, electrocardiogram; LDF, laser Doppler flowmetry; MI, microcirculation index; RCBF, reserve of cutaneous blood flow.

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Tikhonova, I.V., Tankanag, A.V., Guseva, I.E. et al. Analysis of Oscillatory Processes in the Cardiovascular System in Response to Local Heating in Patients with Type 2 Diabetes Mellitus. BIOPHYSICS 68, 1076–1084 (2023). https://doi.org/10.1134/S0006350923060180

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  • DOI: https://doi.org/10.1134/S0006350923060180

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