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A Study of the Antioxidative and Radioprotective Properties of Isobornylphenols during X-Ray Irradiation at a Low Dose

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Abstract

The inhibitory efficiency and radioprotective properties of two isobornylphenols were studied during their administration 30 minutes before X-ray irradiation of outbreed mice (females) at a dose of 50 sGy. It was found that 1,3-dihydroxy-4,6-diisopropylbenzene exhibited high efficiency due to its interaction with peroxy radicals. The spleen index and the content of the lipid peroxidation products in blood plasma, which were previously suggested as tests for the assessment of the radioprotective properties of substances during the irradiation of animals at low doses, returned to the norm with the prophylactic administration of 2-isobornyloxyphenols. An aqueous solution of ethanol was found to be unfavorable as a solvent for the administration of hydrophobic substances under the effects of weak radiation. The data we obtained and the literature analysis allow us to propose isobornylphenols as radioprotective agents during radiation at different doses.

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Funding

This work was financially supported by the Russian Foundation for Basic Research (project no. 15-29-01220 ofi_m).

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Authors and Affiliations

  1. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334, Moscow, Russia

    L. N. Shishkina, A. Yu. Babkin, M. A. Klimovich, M. V. Kozlov, L. I. Mazaletskaya & N. I. Sheludchenko

  2. Institute of Chemistry, Komi Scientific Center, Ural Branch, Russian Academy of Sciences, 167000, Syktyvkar, Komi Republic, Russia

    I. Yu. Chukicheva, I. V. Fedorova & A. V. Kutchin

Authors
  1. L. N. Shishkina
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  2. A. Yu. Babkin
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  3. M. A. Klimovich
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  4. M. V. Kozlov
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  5. L. I. Mazaletskaya
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  6. N. I. Sheludchenko
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  7. I. Yu. Chukicheva
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  8. I. V. Fedorova
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  9. A. V. Kutchin
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Correspondence to L. N. Shishkina.

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All applicable international, national and institutional principles for the care and use of animals in the performance of work have been observed.

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Shishkina, L.N., Babkin, A.Y., Klimovich, M.A. et al. A Study of the Antioxidative and Radioprotective Properties of Isobornylphenols during X-Ray Irradiation at a Low Dose. BIOPHYSICS 64, 984–990 (2019). https://doi.org/10.1134/S0006350919060198

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  • DOI: https://doi.org/10.1134/S0006350919060198

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