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Diode Laser Spectroscopy for Creating Effective Measuring Systems and Their Use in Biological and Medical Research

  • MOLECULAR BIOPHYSICS
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Abstract

In this paper, we present the most important principles of diode laser spectroscopy, which allow one to create fundamentally new measuring systems for diverse applications in biology and medicine. Using the diode laser spectroscopy method and its primary hardware implementation the emission of gas molecules from skin of the hand was registered and ammonia skin emission was found to be dominant. The properties of exhaled air from patients in different states were determined with another special measuring complex of diode laser spectroscopy. It was shown that when the functional state of the body changes, the gas composition of molecular substances that are present in the exhaled air is altered indirectly and their levels vary significantly depending on the health of the individual. Our findings suggest that it is possible to study the specific functional properties of the human body to facilitate assessment of the health of an individual to determine whether pathological processes occur in the body at various stages of their severity using diode laser spectroscopy. This paper presents clinical and experimental data on this issue.

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Authors and Affiliations

  1. Prokhorov General Physics Institute, Russian Academy of Sciences, 119991, Moscow, Russia

    Ya. Ya. Ponurovskii, V. Ya. Zaslavskii, A. I. Nadezhdinskii, M. V. Spiridonov, D. B. Stavrovskii & Yu. P. Shapovalov

  2. Pirogov Russian National Research Medical University, 117997, Moscow, Russia

    A. A. Karabinenko & Yu. M. Petrenko

Authors
  1. Ya. Ya. Ponurovskii
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  2. V. Ya. Zaslavskii
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  3. A. I. Nadezhdinskii
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  4. M. V. Spiridonov
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  5. D. B. Stavrovskii
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  6. Yu. P. Shapovalov
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  7. A. A. Karabinenko
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  8. Yu. M. Petrenko
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Corresponding author

Correspondence to Ya. Ya. Ponurovskii.

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Conflict of interests. The authors declare that they have no conflict of interest.

Statement of compliance with standards of research involving humans as subjects. All procedures performed in the human study were in accordance with the ethical standards of the 1964 Helsinki Declaration and its subsequent revisions. Informed voluntary consent was obtained from each of the participants included in the study.

Additional information

Translated by M. Novikova

Abbreviations: DLS, diode laser spectroscopy; GI, gastrointestinal tract, PUac, peptic ulcer in acute phase; PUrem, peptic ulcer in remission phase; HR, heart rate.

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Ponurovskii, Y.Y., Zaslavskii, V.Y., Nadezhdinskii, A.I. et al. Diode Laser Spectroscopy for Creating Effective Measuring Systems and Their Use in Biological and Medical Research. BIOPHYSICS 64, 870–884 (2019). https://doi.org/10.1134/S0006350919060186

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  • DOI: https://doi.org/10.1134/S0006350919060186

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