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The Molecular mechanism of the action of Helianthus tuberosus L. polysaccharide

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Abstract

Evidence for immunoadjuvant activity of the Helianthus tuberosus L. polysaccharide was obtained in an antibody-producing cell model. Dectin-1 and TLR-6 were identified as major receptors required for biological activity of polysaccharide in a TNF-α stimulation model. The CR3 receptor was not implicated in polysaccharide recognition in the same model. Enzyme treatment of the H. tuberosus L. polysaccharide demonstrated the presence of ß-(1 → 4) and ß-(1 → 3) glycosidic bonds.

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Abbreviations

TLR:

Toll-like receptor

HRLP:

Helianthus tuberosus L. polysaccharide

LPS:

lipopolysaccharide

TNF:

tumor necrosis factor

References

  1. Y. Bulut, E. Faure, L. Thomas, et al., J. Immunol. 167 (2), 987 (2001).

    Article  Google Scholar 

  2. N. D. Titova, Immunopatol. Allergol. Infektol. 3, 32 (2009).

    Google Scholar 

  3. Y. Xia, V. Vetvicka, J. Yan, et al., J. Immunol. 162 (4), 2281 (1999).

    Google Scholar 

  4. G. D. Brown, P. R. Taylor, D. M. Reid, et al., J. Exp. Med. 196 (3), 407 (2002).

    Article  Google Scholar 

  5. A. M. Kerrigan and G. D. Brown, Trends Immunol., 32, 151 (2011).

    Article  Google Scholar 

  6. H. Chen, H. Cai, L. Chen, et al., Clin. Invest. Med. 34 (2), 71 (2011).

    Google Scholar 

  7. D. Akramiene, A. Kondrotas, J. Didziapetriene, and E. Kevelaitis, Medicina (Kaunas) 43, 597 (2007).

    Google Scholar 

  8. S. Hanashima, A. Ikeda, and H. Tanaka, Glycoconj. J. 31 (3), 199 (2014).

    Article  Google Scholar 

  9. Y. Ikeda, Y. Adachi, T. Ishii, et al., Biol. Pharm. Bull. 31 (1), 13 (2008).

    Article  Google Scholar 

  10. S. E. Hardison and G. D. Brown, Nat. Immunol. 13, 817 (2012).

    Article  Google Scholar 

  11. Fuller G.L., Williams J.A., Tomlinson M.G., et al., J. Biol. Chem. 282, 12397 (2007).

    Article  Google Scholar 

  12. KEGG Data Base. http://www.genome.jp/keggbin/show_pathway?map=hsa04620&show_description=show.

  13. B. A. Stone and A. E. Clarke, Chemistry and Biology of 1,3-ß-Glucans (Vic. La Trobe Univ. Press, Bundoora, 1992).

    Google Scholar 

  14. J.-S. Lin, J. H. Huang, L.-Y. Hung, et al., J. Leukoc. Biol. 88 (1), 95 (2010).

    Article  Google Scholar 

  15. C. Gillaux, C. Méhats, D. Vaiman, et al., J. Immunol. 187 (5), 2766 (2011).

    Article  Google Scholar 

  16. Q. Zhang, W. Hui, G. J. Litherland, et al., Ann. Rheum. Dis. 67 (11), 1633 (2008).

    Article  Google Scholar 

  17. S. Ganesan, V. A. K. Rathinam, L. Bossaler, et al., J. Immunol. 193 (5), 2519 (2014).

    Article  Google Scholar 

  18. W. C. Moss, D. J. Irvine, M. M. Davis, and M. F. Krummel, Proc. Natl. Acad. Sci. USA. 99 (23), 15024 (2002).

    Article  ADS  Google Scholar 

Download references

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Authors and Affiliations

  1. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow, 119991, Russia

    E. A. Generalov & A. I. Afremova

Authors
  1. E. A. Generalov
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  2. A. I. Afremova
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Correspondence to E. A. Generalov or A. I. Afremova.

Additional information

Original Russian Text © E.A. Generalov, A.I. Afremova, 2016, published in Biofizika, 2016, Vol. 61, No. 4, pp. 660–668.

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Generalov, E.A., Afremova, A.I. The Molecular mechanism of the action of Helianthus tuberosus L. polysaccharide. BIOPHYSICS 61, 558–564 (2016). https://doi.org/10.1134/S0006350916040096

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  • DOI: https://doi.org/10.1134/S0006350916040096

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