Nanocomposite regeneration systems for wound healing

Abstract

The regeneration system “Biokol” based on the principles of combining synthetic and natural biopolymers has been investigated. The wound dressing consists of “large” (200–250 nm) particles of a synthetic biopolymer and a gel component, which consists of “small” polysaccharide elements 10–20 nm in size. The system can be used both separately and in combination with the gel complex and cell cultures. In properties (vapor and gas permeability, mechanical properties, conductivity, resistance to microbes, etc.), it corresponds to the upper layer of the skin. When applied to the wound, the dressing changes its adhesiveness: first, owing to its hydrophilicity and low hydrophobicity, it closely adheres to the wound surface, and after some time, which corresponds to the time the polysaccharide complex is released from the dressing, it becomes hydrophobic and easily separates from the wound. Owing to these properties, the system can be used at all stages of wound healing.