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Detection of large deletions of mitochondrial DNA in tissues of mice exposed to X-rays

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Abstract

Large mtDNA deletions in mouse brain and spleen cells, induced by X-radiation at doses of 2 and 5 Gy were studied within four weeks after the exposure of animals to X-rays. Variations in the content of extra-cellular deleted mtDNA were examined in the blood plasma of mice irradiated with 5 Gy in the same postir-radiation times. Ionizing radiation was shown to effectively induce large mtDNA deletions at the doses chosen. The level of deletion mtDNA was dependent on dose and postirradiation time.

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Authors and Affiliations

  1. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia

    V. N. Antipova, L. V. Malakhova & V. G. Bezlepkin

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  1. V. N. Antipova
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  2. L. V. Malakhova
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  3. V. G. Bezlepkin
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Correspondence to V. N. Antipova.

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Original Russian Text © V.N. Antipova, L.V. Malakhova, V.G. Bezlepkin, 2011, published in Biofizika, 2011, Vol. 56, No. 3, pp. 439–445.

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Antipova, V.N., Malakhova, L.V. & Bezlepkin, V.G. Detection of large deletions of mitochondrial DNA in tissues of mice exposed to X-rays. BIOPHYSICS 56, 423–428 (2011). https://doi.org/10.1134/S0006350911030031

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  • DOI: https://doi.org/10.1134/S0006350911030031

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