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Age-related changes in the functioning of the mitochondrial potassium-transporting system

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Abstract

Changes in the rate of respiration and functioning of the ATP-dependent potassium channel in liver and heart mitochondria of one-, three-, eight-, and 24-month-old Wistar male rats have been investigated. It was shown that the activity of the channel in the mitochondria of both tissues in 24-month-old animals decreases more than three times, and the content of potassium, 1.5–2 times compared with young one-month-old rats. The changes occur against the background of age-related decrease of energy supply in mitochondria, the respiratory complex-I undergoing the greatest changes upon aging. The decrease of channel activity may be the result of changes in channel sensitivity to modulators and a decrease in the expression of mitochondrial K+-transporting channel-protein with a molecular mass of 5.5 kDa upon aging found in this work. As a result, the functioning of not only the mitoKATP but also the whole mitochondrial potassium cycle is impaired.

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Authors and Affiliations

  1. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia

    M. I. Shigaeva, E. N. Gritsenko, S. V. Murzaeva, O. S. Gorbacheva, E. Yu. Talanov & G. D. Mironova

  2. Pushchino State University, Pushchino, Moscow Region, 142290, Russia

    O. S. Gorbacheva, E. Yu. Talanov & G. D. Mironova

Authors
  1. M. I. Shigaeva
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  2. E. N. Gritsenko
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  3. S. V. Murzaeva
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  4. O. S. Gorbacheva
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  5. E. Yu. Talanov
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  6. G. D. Mironova
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Original Russian Text © M.I. Shigaeva, E.N. Gritsenko, S.V. Murzaeva, O.S. Gorbacheva, E.Yu. Talanov, G.D. Mironova, 2010, published in Biofizika, 2010, Vol. 55, No. 6, pp. 1030–1037.

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Shigaeva, M.I., Gritsenko, E.N., Murzaeva, S.V. et al. Age-related changes in the functioning of the mitochondrial potassium-transporting system. BIOPHYSICS 55, 944–950 (2010). https://doi.org/10.1134/S0006350910060102

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  • DOI: https://doi.org/10.1134/S0006350910060102

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