Abstract
Considered are the methodological bases of two radiobiological theories—target theory and structural-metabolic theory. The target theory states the existence in the cell of a biologically significant structure (sensitive volume) and the monotonic “dose-effect“ dependence. In the structural-metabolic theory at the molecular level the unity of structure and metabolism is postulated. Discussed is the role of homeostatic mechanisms in the nonmonotonicity of the “time-effect” dependence. The nonmonotonicity of the “dose-effect” dependence for metabolic and functional parameters of cells and tissues is stipulated by the non-monotonicity in time of the metabolic and functional response to the action of ionizing radiation.
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Original Russian Text © I.K. Kolomiytseva, 2009, published in Biofizika, 2009, Vol. 54, No. 5, pp. 946–952.
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Kolomiytseva, I.K. Methodological aspects of the problem of nonmonotonic dose-effect dependence. BIOPHYSICS 54, 655–660 (2009). https://doi.org/10.1134/S0006350909050182
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DOI: https://doi.org/10.1134/S0006350909050182