Abstract
Studies of mechanical stresses and mechanical feedback at the cell level are reviewed. It is shown that cells and embryonic tissues respond to external mechanical stresses and can generate such stresses themselves. Regular feedback loops between external (passive) and internal (active) mechanical stresses have been established. They are essential for cell survival, determination of the direction of their differentiation, and selforganization of morphogenetic processes. Relevant experimental data are presented, and models of mechanical feedback loops are discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Abbreviations
- MSs:
-
mechanical stresses
References
Yu. M. Romanovskii, N. V. Stepanova, and D. S. Chernakskii, Mathematical Biophysics (Nauka, Moscow, 1984) [in Russian].
L. A. Martynov, Mathematical Developmental Biophysics, Ed. by A. I. Zotin and E. V. Presnov (Nauka, Moscow, 1982) [in Russian].
A. K. Harris, D. Stopak, and P. Warner, J. Embryol. Exp. Morphol. 80, 1 (1984).
B. N. Belintsev, Physical Basics of Biological Morphogenesis (Nauka, Moscow, 1991) [in Russian].
C. S. Chen, M. Mrksich, S. Huang, et al., Science 276, 1425 (1997).
C. M. Nelson, R. P. Jean, J. L. Tan, et al. Proc. Natl. Acad. Sci. U.S.A. 102, 11594 (2005).
R. McBeath, D. M. Pirone, C. M. Nelson, et al., Dev. Cell 6, 483 (2004).
A. J. Engler, Shamik Sen, H. Lee Sweeney, et al., Cell 126, 677 (2006).
M. J. Paszek, N. Zahir, K. R. Johnson, et al. Cancer Cell 8, 241 (2005).
H. Huang, R. D. Kamm, and R. T. Lee, Am. J. Physiol. Cell Physiol. 287, C1 (2004).
D. M. Pirone, W. F. Liu, S. A. Ruiz, et al., J. Cell Biol. 174, 277 (2006).
E. Farge, Curr. Biol. 13, 1365 (2003).
C. H. Thomas, J. H. Collier, S. C. Sfeir, et al., PNAS 99, 1972 (2002).
N. Itano, S. Okamoto, D. Shang, et al., PNAS 100, 5181 (2003).
G. M. Odett, G. Oster, F. Alberch, et al., Devel. Biol. 85, 446 (1981).
L. V. Beloussov, Phys. Biol. 5, 015009 (2008).
L. V. Beloussov and V. I. Grabovsky, Biosystems 87, 204 (2007).
L. V. Beloussov, N. N. Louchinskaia, A. S. Ermakov, et al., Int. J. Dev. Biol. 50, 113 (2006).
T. G. Troshina and L. V. Beloussov, Ontogenez (in press).
V. A. Teplov, Biological Mortality, Ed. by Z. A. Podlubnaya and S. L. Malyshev (Pushchino, 2008).
Author information
Authors and Affiliations
Additional information
Original Russian Text © L.V. Beloussov, T.G. Troshina, A.N. Mansurov, 2008, published in Biofizika, 2008, Vol. 53, No. 6, pp. 1038–1043.
Rights and permissions
About this article
Cite this article
Beloussov, L.V., Troshina, T.G. & Mansurov, A.N. Mechanical feedback in morphogenesis and cell differentiation. BIOPHYSICS 53, 575–579 (2008). https://doi.org/10.1134/S0006350908060201
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0006350908060201