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The effect of taurine on the ion transport system in mitochondria

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Abstract

The effect of taurine on the ATP-dependent mitochondrial swelling that characterizes the activity of mitochondrial ATP-dependent K+ channel and the formation of Ca2+-dependent pores, different in sensitivity to cyclosporin A, has been studied in rat liver mitochondria. It has been shown that taurine in micromolar concentrations (0.5–125 μM) stimulates the energy-dependent swelling of mitochondria. Taurine in physiological concentrations (0.5–20 mM) has no effect on the ATP-dependent swelling and the formation of cyclosporin A-insensitive Pal/Ca2+-activated pore in mitochondria. Taurine in these concentrations increased the rate of cyclosporin A-sensitive swelling of mitochondria induced by Ca2+ and Pi and reduced the Ca2+ capacity of mitochondria. The different effects of physiological taurine concentrations on the ATP-dependent transport of K+ and Ca2+ ions in mitochondrial membranes as compared with cell membranes are discussed.

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Abbreviations

MPT:

mitochondrial permeability transition pore

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Authors and Affiliations

  1. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, ul. Institutskaya 3, Pushchino, Moscow oblast, 142290, Russia

    S. V. Murzaeva, N. V. Belosludtseva & G. D. Mironova

  2. Federal Institution Research Institute of Experimental Medicine, Russian Academy of Medical Sciences, ul. Akademika Pavlova 12, St.-Petersburg, 197376, Russia

    L. Gavrovskaya

Authors
  1. S. V. Murzaeva
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  2. N. V. Belosludtseva
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  3. L. Gavrovskaya
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  4. G. D. Mironova
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Corresponding author

Correspondence to S. V. Murzaeva.

Additional information

Original Russian Text © S.V. Murzaeva, N.V. Belosludtseva, L. Gavrovskaya, G.D. Mironova, 2008, published in Biofizika, 2008, Vol. 53, No. 6, pp. 962–966.

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Murzaeva, S.V., Belosludtseva, N.V., Gavrovskaya, L. et al. The effect of taurine on the ion transport system in mitochondria. BIOPHYSICS 53, 515–518 (2008). https://doi.org/10.1134/S0006350908060080

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  • DOI: https://doi.org/10.1134/S0006350908060080

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