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Discovery and Study of Transmembrane Rotary Ion-Translocating Nano-Motors: F-ATPase/Synthase of Mitochondria/Bacteria and V-ATPase of Eukaryotic Cells

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Abstract

This review discusses the history of discovery and study of the operation of the two rotary ion-translocating ATPase nano-motors: (i) F-ATPase/synthase (holocomplex F1FO) of mitochondria/bacteria and (ii) eukaryotic V-ATPase (holocomplex V1VO). Vacuolar adenosine triphosphatase (V-ATPase) is a transmembrane multisubunit complex found in all eukaryotes from yeast to humans. It is structurally and functionally similar to the F-ATPase/synthase of mitochondria/bacteria and the A-ATPase/synthase of archaebacteria, which indicates a common evolutionary origin of the rotary ion-translocating nano-motors built into cell membranes and invented by Nature billions of years ago. Previously we have published several reviews on this topic with appropriate citations of our original research. This review is focused on the historical analysis of the discovery and study of transmembrane rotary ion-translocating ATPase nano-motors functioning in bacteria, eukaryotic cells and mitochondria of animals.

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Abbreviations

ΔµH+ :

proton-motive force of transmembrane electrochemical transmembrane proton gradient

EP:

elementary particles

factor F1 :

cytoplasmic part of holocomplex F1FO

factor FO :

transmembrane part of holocomplex F1FO

factor V1 :

cytoplasmic part of holocomplex V1VO

factor VO :

transmembrane part of holocomplex V1VO

holocomplex F1FO :

F-ATPase/synthase of mitochondria/bacteria

holocomplex V1VO :

eukaryotic vacuolar adenosine triphosphatase (V-ATPase)

SMP:

submitochondrial particles

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    Vladimir Marshansky

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Marshansky, V. Discovery and Study of Transmembrane Rotary Ion-Translocating Nano-Motors: F-ATPase/Synthase of Mitochondria/Bacteria and V-ATPase of Eukaryotic Cells. Biochemistry Moscow 87, 702–719 (2022). https://doi.org/10.1134/S000629792208003X

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