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Phospholipase Superfamily: Structure, Functions, and Biotechnological Applications

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Abstract

Enzymes of the phospholipase superfamily are involved in lipid metabolism, as well as regulation of membrane composition, cell signaling, and inflammation. This review provides an insight into the structure, functional properties, and biotechnological application of phospholipase A2 and phospholipases in general.

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Abbreviations

cPLA2:

cytosolic phospholipase A2

IP3:

inositol 1,4,5-trisphosphate

iPLA2:

calcium-independent phospholipase A2

PAF:

platelet-activating factor

PAF-AH:

platelet-activating factor acetylhydrolase

PIP2:

phosphatidylinositol 4,5-bisphosphate

PLA1(2):

phospholipase A1(2)

PLB(C,D):

phospholipase B(C,D)

sPLA2:

secretory phospholipase A2

sPLA2R:

secretory phospholipase A2 receptor

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Funding

Funding This study was supported by the Ministry of Science and Higher Education of the Russian Federation (agreement no. 14.607.21.0207; RFMEFI60718X0207; 31.05.2018) within the framework of the Federal Target Program “Research and Development in the Priority Areas of the Science and Technology Complex of Russia for 2014-2020”.

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  1. Bach Institute of Biochemistry, Federal Research Center “Fundamentals of Biotechnology”, Russian Academy of Sciences, 119071, Moscow, Russia

    S. Yu. Filkin, A. V. Lipkin & A. N. Fedorov

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  1. S. Yu. Filkin
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  2. A. V. Lipkin
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  3. A. N. Fedorov
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Ethical approval This article does not contain description of studies with human participants or animals performed by any of the authors.

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Russian Text © The Author(s), 2020, published in Uspekhi Biologicheskoi Khimii, 2020, Vol. 60, pp. 369–410.

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Filkin, S.Y., Lipkin, A.V. & Fedorov, A.N. Phospholipase Superfamily: Structure, Functions, and Biotechnological Applications. Biochemistry Moscow 85 (Suppl 1), 177–195 (2020). https://doi.org/10.1134/S0006297920140096

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