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Molecular Mechanisms of Pathologies of Skeletal and Cardiac Muscles Caused by Point Mutations in the Tropomyosin Genes

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Abstract

The review is devoted to tropomyosin (Tpm)–actin-binding protein, which plays a crucial role in the regulation of contraction of skeletal and cardiac muscles. Special attention is paid to myopathies and cardiomyopathies–severe hereditary diseases of skeletal and cardiac muscles associated with point mutations in Tpm genes. The current views on the molecular mechanisms of these diseases and the effects of such mutations on the Tpm structure and functions are considered in detail. Besides, some part of the review is devoted to analysis of the properties of Tpm homodimers and heterodimers with myopathic substitutions of amino acid residues in only one of the two chains of the Tpm dimeric molecule.

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Abbreviations

Tpm:

tropomyosin

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Funding

Funding. This work was supported by the Russian Foundation for Basic Research (project 17-00-00065).

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Authors and Affiliations

  1. Bach Institute of Biochemistry, Federal Research Center on Fundamentals of Biotechnology, Russian Academy of Sciences, 119071, Moscow, Russia

    A. M. Matyushenko & D. I. Levitsky

  2. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992, Moscow, Russia

    D. I. Levitsky

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  1. A. M. Matyushenko
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Correspondence to A. M. Matyushenko or D. I. Levitsky.

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Russian Text © The Author(s), 2020, published in Uspekhi Biologicheskoi Khimii, 2020, Vol. 60, pp. 43–74.

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Matyushenko, A.M., Levitsky, D.I. Molecular Mechanisms of Pathologies of Skeletal and Cardiac Muscles Caused by Point Mutations in the Tropomyosin Genes. Biochemistry Moscow 85 (Suppl 1), 20–33 (2020). https://doi.org/10.1134/S0006297920140023

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