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Search for Intracellular Sensors Involved in the Functioning of Monovalent Cations as Secondary Messengers

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Abstract

Maintenance of non-equilibrium Na+ and K+ distribution between cytoplasm and extracellular medium suggests existence of sensors responding with conformational transitions to the changes of these monovalent cations’ intracellular concentration. Molecular nature of monovalent cation sensors has been established in Na,K-ATPase, G-protein-coupled receptors, and heat shock proteins structural studies. Recently, it was found that changes in Na+ and K+ intracellular concentration are the key factors in the transcription and translation control, respectively. In this review, we summarize results of these studies and discuss physiological and pathophysiological significance of \({\rm{Na}}_{\rm{i}}^+,{\rm{K}}_{\rm{i}}^+\)-dependent gene expression regulation mechanism.

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Abbreviations

AMPK:

AMP-activated protein kinase

CaMK:

Ca2+/calmodulin-dependent protein kinase

COX-2:

cyclooxygenase type 2

CREB:

cyclic AMP response element-binding protein

CTS:

cardiotonic steroids

EPS:

electrical pulse stimulation

ERG:

early response gene

GPCR:

G-protein-coupled receptor

HIF-1:

hypoxia-inducible factor 1

HRE:

HIF-response element

HSP:

heat shock protein

NaRE:

identified Na+ response element, gene transcription regulator

NaREB:

unidentified [Na+]i sensor, NaRE activator

NBD:

nucleotidebinding domain

NFAT:

nuclear factor of activated T cells

NFκB:

nuclear factor kappa-light chain enhancer of activated B cells

NMDA:

N-methyl-D-aspartate

SBD:

substrate-binding domain

SERCA:

skeletal muscle sarcoplasmic/endoplasmic-reticulum Ca-ATPase

SMC:

smooth muscle cell

UTR:

untranslated mRNA region

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Acknowledgements

The authors express their gratitude to Prof. A. A. Mongin (Albany Medical College, USA) for reading this review and providing critical comments.

Funding

This work was supported by the Russian Science Foundation (project 16-15-10026-p, section “Physiological and pathophysiological significance of Na +i ,K +i -dependent mechanism of gene expression regulation”) and Russian Foundation for Basic Research (project 18-04-00063, sections “Identified sensors of monovalent cations”, “Sodium as transcription regulator”, and “Potassium as translation regulator”).

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Authors and Affiliations

  1. Department of Biology, Lomonosov Moscow State University, 119234, Moscow, Russia

    E. A. Klimanova, S. V. Sidorenko, A. M. Tverskoi, A. A. Shiyan, L. V. Smolyaninova, G. V. Maksimov, O. D. Lopina & S. N. Orlov

  2. National Research Tomsk State University, 634050, Tomsk, Russia

    L. V. Kapilevich & S. N. Orlov

  3. Siberian State Medical University, Ministry of Health of Russian Federation, 634050, Tomsk, Russia

    S. V. Gusakova & S. N. Orlov

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  1. E. A. Klimanova
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  2. S. V. Sidorenko
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  3. A. M. Tverskoi
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  4. A. A. Shiyan
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  5. L. V. Smolyaninova
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  6. L. V. Kapilevich
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  8. G. V. Maksimov
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  9. O. D. Lopina
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  10. S. N. Orlov
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Correspondence to E. A. Klimanova.

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The authors declare no conflict of interest in financial or any other sphere.

Ethical approval

All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

Russian Text © The Author(s), 2019, published in Biokhimiya, 2019, Vol. 84, No. 11, pp. 1592–1609.

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Klimanova, E.A., Sidorenko, S.V., Tverskoi, A.M. et al. Search for Intracellular Sensors Involved in the Functioning of Monovalent Cations as Secondary Messengers. Biochemistry Moscow 84, 1280–1295 (2019). https://doi.org/10.1134/S0006297919110063

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