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Inorganic Polyphosphate and Cancer

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Abstract

This review presents data on the relationship between inorganic polyphosphate metabolism and carcinogenesis including participation of polyphosphates in the regulation of activity of mTOR and other proteins involved in carcinogenesis, the role of h-prune protein (human polyphosphatase) in cell migration and metastasis formation, the prospects for using polyphosphates and inhibitors of polyphosphate metabolism enzymes as agents for controlling cell proliferation and migration.

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  1. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, 142290, Pushchino, Moscow Region, Russia

    E. V. Kulakovskaya, M. Yu. Zemskova & T. V. Kulakovskaya

  2. Moscow State Regional University, Research and Education Center of Pushchino, 142290, Pushchino, Moscow Region, Russia

    M. Yu. Zemskova

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  1. E. V. Kulakovskaya
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Original Russian Text © E. V. Kulakovskaya, M. Yu. Zemskova, T. V. Kulakovskaya, 2018, published in Biokhimiya, 2018, Vol. 83, No. 8, pp. 1211–1219.

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Kulakovskaya, E.V., Zemskova, M.Y. & Kulakovskaya, T.V. Inorganic Polyphosphate and Cancer. Biochemistry Moscow 83, 961–968 (2018). https://doi.org/10.1134/S0006297918080072

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