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New titin (connectin) isoforms and their functional role in striated muscles of mammals: Facts and suppositions

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Abstract

This review summarizes results of our studies on titin isoform composition in vertebrate striated muscles under normal conditions, during hibernation, real and simulated microgravity, and under pathological conditions (stiff-person syndrome, post-apoplectic spasticity, dilated cardiomyopathy, cardiac hypertrophy). Experimental evidence for the existence in mammalian striated muscles of higher molecular weight isoforms of titin (NT-isoforms) in addition to the known N2A-, N2BA-, and N2B-titin isoforms was obtained. Comparative studies of changes in titin isoform composition and structure-functional properties of human and animal striated muscles during adaptive and pathological processes led to a conclusion about the key role of NT-isoforms of titin in maintenance of sarcomere structure and contractile function of these muscles.

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Abbreviations

cDNA:

complementary deoxyribonucleic acid

DCM:

dilated cardiomyopathy

LV:

left ventricle of heart

MHC:

myosin heavy chains

SHR:

spontaneously hypertensive rats

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Authors and Affiliations

  1. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, ul. Institutskaya 3, 142290, Pushchino, Moscow Region, Russia

    I. M. Vikhlyantsev & Z. A. Podlubnaya

  2. Pushchino State Institute of Natural Sciences, pr. Nauki 3, 142290, Pushchino, Moscow Region, Russia

    Z. A. Podlubnaya

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  1. I. M. Vikhlyantsev
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  2. Z. A. Podlubnaya
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Correspondence to I. M. Vikhlyantsev.

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Original Russian Text © I. M. Vikhlyantsev, Z. A. Podlubnaya, 2012, published in Uspekhi Biologicheskoi Khimii, 2012, Vol. 52, pp. 239–280.

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Vikhlyantsev, I.M., Podlubnaya, Z.A. New titin (connectin) isoforms and their functional role in striated muscles of mammals: Facts and suppositions. Biochemistry Moscow 77, 1515–1535 (2012). https://doi.org/10.1134/S0006297912130093

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