Skip to main content
SpringerLink
Log in

Effect of plastoquinone derivative 10-(6′-Plastoquinonyl) decyltriphenylphosphonium (SkQ1) on estrous cycle and 17β-estradiol level in rats

  • Published:
Biochemistry (Moscow) Aims and scope Submit manuscript

Abstract

Administration of the plastoquinone derivative 10-(6′-plastoquinonyl)decyltriphenylphosphonium (SkQ1) to female Wistar rats with regular estrous cycle once a day for two weeks at doses of 25 nmol/kg (but not 250 nmol/kg) leads to increase in proestrus duration by reducing the phase of diestrus and metestrus. Neither dose caused significant changes in serum 17β-estradiol level for any stage of the cycle. However, relative elongation of the proestrus stage leads to an increase in average per cycle estradiol levels by 20%.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

LPO:

lipid peroxidation

\(O_2^{\bar \cdot }\) :

superoxide anion radical

ROS:

reactive oxygen species

SkQ1:

plastoquinone derivative 10-(6′-plastoquinonyl)decyltriphenylphosphonium

References

  1. Anisimov, V. N., Bakeeva, L. E., Egormin, P. A., Filenko, O. F., Isakova, E. F., Manskikh, V. N., Mikhelson, V. M., Panteleeva, A. A., Pasyukova, E. G., Pilipenko, D. I., Piskunova, T. S., Popovich, I. G., Roshchina, N. V., Rybina, O. Yu., Saprunova, V. B., Samoylova, T. A., Semenchenko, A. V., Skulachev, M. V., Spivak, I. M., Tsybul’ko, E. A., Tyndyk, M. L., Vyssokikh, M. Yu., Yurova, M. N., Zabezhinsky, M. A., and Skulachev, V. P. (2008) Biochemistry (Moscow), 73, 1329–1342.

    Article  CAS  Google Scholar 

  2. Skulachev, V. P., Anisimov, V. N., Antonenko, Y. N., Bakeeva, L. E., Chernyak, B. V., Erichev, V. P., Filenko, O. F., Kalinina, N. I., Kapelko, V. I., Kolosova, N. G., Kopnin, B. P., Korshunova, G. A., Lichinitser, M. R., Obukhova, L. A., Pasyukova, E. G., Pisarenko, O. I., Roginsky, V. A., Ruuge, E. K., Senin, I. I., Severina, I. I., Skulachev, M. V., Spivak, I. M., Tashlitsky, V. N., Tkachuk, V. A., Vyssokikh, M. Y., Yaguzhinsky, L. S., and Zorov, D. B. (2009) Biochim. Biophys. Acta, 1787, 437–461.

    Article  PubMed  CAS  Google Scholar 

  3. Chistyakov, V. A., Serezhenkov, V. A., Alexandrova, A. A., Milyutina, N. P., Prokof’ev, V. N., Mashkina, E. V., Gutnikova, L. V., and Dem’yanenko, S. V. (2010) Biochemistry (Moscow), 75, 1383–1387.

    Article  CAS  Google Scholar 

  4. Komarov, F. I., and Rapoport, S. I. (2000) Chronobiology and Chronomedicine [in Russian], Triada-X, Moscow.

    Google Scholar 

  5. Kabak, Ya. M. (1968) Practicum in Endocrinology. Basic Techniques of Experimental Endocrinology Research [in Russian], Moscow State University Publishers, Moscow.

    Google Scholar 

  6. Bessalova, Ye. Yu. (2006) Klin. Anat. Oper. Hirurg. (Ukr.), 5, 85–90.

    Google Scholar 

  7. Smith, M. S., Freeman, M. E., and Neill, J. D. (1975) Endocrinology, 96, 219–226.

    Article  PubMed  CAS  Google Scholar 

  8. Steinberg, R. M., Walker, D. M., Juenger, T. E., and Woller, M. J. (2008) Biol. Reprod., 78, 1091–1101.

    Article  PubMed  CAS  Google Scholar 

  9. Vinogradova, I. A., and Chernova, I. V. (2006) Uspekhi Gerontol., 19, 60–65.

    CAS  Google Scholar 

  10. Walf, A. A., Koonce, C., Manley, K., and Frye, C. A. (2009) Behav. Brain Res., 196, 254–260.

    Article  PubMed  CAS  Google Scholar 

  11. Duran, R. G., Gomez Melendez, M. R., and Hicks Comez, J. J. (1998) Ginecol. Obstet. Mex., 66, 371–376.

    Google Scholar 

  12. Lomteva, N. A. (2008) Probl. Reprod., 6, 12–15.

    Google Scholar 

  13. Navarro, A., and Torrejon, R. (2007) Front. Biosci., 1, 1164–1173.

    Article  Google Scholar 

  14. Cameron, I. T., and Campbell, S. (1998) Hum. Reprod. Update, 4, 565–569.

    Article  PubMed  CAS  Google Scholar 

  15. Van Voorhis, B. J., Moore, K., Strijbos, P. J. L., Nelson, S., Baylis, S. A., Grzybicki, D., and Weiner, C. P. (1995) J. Clin. Invest., 96, 2719–2726.

    Article  PubMed  Google Scholar 

  16. Burlakova, Ye. B., Grechenko, T. N., Sokolov, Ye. N., and Terekhova, S. F. (1986) Biofizika, 34, 9–21.

    Google Scholar 

  17. Ashmarin, I. P., Karazeeva, Ye. P., and Lelekova, T. V. (1999) Ros. Khim. Zh., 5, 21.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research Institute of Biology of Southern Federal University, pr. Stachki 194/1, 344090, Rostov-on-Don, Russia

    V. A. Chistyakov, S. V. Dem’yanenko, A. A. Alexandrova, L. V. Gutnikova, V. N. Prokof’ev & O. N. Kosheleva

  2. Central Research Laboratory, Rostov State Medical University, Pereulok Nakhichevansky 29, 344022, Rostov-on-Don, Russia

    V. A. Chistyakov & S. V. Dem’yanenko

Authors
  1. V. A. Chistyakov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. V. Dem’yanenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. A. Alexandrova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. L. V. Gutnikova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. V. N. Prokof’ev
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. O. N. Kosheleva
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to V. A. Chistyakov.

Additional information

Original Russian Text © V. A. Chistyakov, S. V. Dem’yanenko, A. A. Alexandrova, L. V. Gutnikova, V. N. Prokof’ev, O. N. Kosheleva, 2012, published in Biokhimiya, 2012, Vol. 77, No. 12, pp. 1699–1704.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chistyakov, V.A., Dem’yanenko, S.V., Alexandrova, A.A. et al. Effect of plastoquinone derivative 10-(6′-Plastoquinonyl) decyltriphenylphosphonium (SkQ1) on estrous cycle and 17β-estradiol level in rats. Biochemistry Moscow 77, 1382–1386 (2012). https://doi.org/10.1134/S0006297912120061

Download citation

  • Received:

  • Revised:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0006297912120061

Key words

Search

Navigation