Abstract
Cytokinin oxidase (EC 1.5.99.12) is an enzyme that catalyzes the irreversible degradation of cytokinin phytohormones that are extremely necessary for growth, development, and differentiation of plants. Cytokinin oxidase plays an important role in the regulation of quantitative level of cytokinins and their distribution in plant tissues. This review generalizes the available information on the structure, properties, and functional role of this enzyme in plant ontogeny under conditions of normal growth and under the influence of unfavorable environmental factors.
Similar content being viewed by others
References
Sakakibara, H. (2006) Annu. Rev. Plant Biol., 57, 431–449.
Zubo, Y. O., Yamburenko, M. V., Selivankina, S. Y., Shakirova, F. M., Avalbaev, A. M., Kudryakova, N. V., Zubkova, N. K., Liere, K., Kulaeva, O. N., Kusnetsov, V. V., and Borner, T. (2008) Plant Physiol., 148, 1082–1093.
Perilli, S., Moubayidin, L., and Sabatini, S. (2010) Curr. Opin. Plant Biol., 13, 21–26.
Gajdosova, S., Spichal, L., Kaminek, M., Hoyerova, K., Novak, O., Dobrev, P. I., Galuszka, P., Klima, P., Gaudinova, A., Zizkova, E., Hanus, J., Dancak, M., Travnicek, B., Pesek, B., Krupicka, M., Vankova, R., Strnad, M., and Motyka, V. (2011) J. Exp. Bot., 62, 2827–2840.
Brovko, F. A., Vasil’eva, V. S., Shepelyakovskaya, A. O., Selivankina, S. Y., Kudoyarova, G. R., Nosov, A. V., Moshkov, D. A., Laman, A. G., Boziev, K. M., Kusnetsov, V. V., and Kulaeva, O. N. (2007) J. Exp. Bot., 58, 2479–2490.
Brovko, F. A., Vasil’eva, V. S., Lushnikova, A. L., Selivankina, S. Y., Karavaiko, N. N., Boziev, K. M., Shepelyakovskaya, A. O., Moshkov, D. A., Pavlik, L. L., Kusnetsov, V. V., and Kulaeva, O. N. (2010) J. Exp. Bot., 61, 3461–3474.
Sykorova, B., Kuresova, G., Daskalova, S., Trckova, M., Hoyerova, K., Raimanova, I., Motyka, V., Travnickova, A., Elliott, M. C., and Kaminek, M. (2008) J. Exp. Bot., 9, 377–387.
Romanov, G. A. (2009) Fiziol. Rast., 56, 295–319.
Garnica, M., Houdusse, F., Zamarreno, A. M., and Garcia-Mina, J. M. (2010) J. Plant Physiol., 167, 1264–1272.
Bartrina, I., Otto, E., Strnad, M., Werner, T., and Schmulling, T. (2011) Plant Cell, 23, 69–80.
Veselov, D. S., Veselov, S. Y., Vysotskaya, L. B., Kudoyarova, G. R., and Farkhutdinov, R. G. (2007) Hormones of Plants. Regulation of Their Concentration and Association with the Growth and Water Exchange [in Russian], Nauka, Moscow.
Chernyad’ev, I. I. (2009) Prikl. Biokhim. Mikrobiol., 45, 389–402.
Argueso, C. T., Ferreira, F. J., and Kieber, J. J. (2009) Plant Cell Environ., 32, 1147–1160.
Rivero, R. M., Shulaev, V., and Blumwald, E. (2009) Plant Physiol., 150, 1530–1540.
Rivero, R. M., Gimeno, J., Van Deynze, A., Walia, H., and Blumwald, E. (2010) Plant Cell Physiol., 51, 1929–1941.
Peleg, Z., Reguera, M., Tumimbang, E., Walia, H., and Blumwald, E. (2011) Plant Biotechnol. J., 9, 747–758.
Kulaeva, O. N. (1973) Cytokinins, Their Structure and Functions [in Russian], Nauka, Moscow.
Ricci, A., and Bertoletti, C. (2009) Plant Biol., 11, 262–272.
Mok, M. C., Martin, R. C., Dobrev, P. I., Vankova, R., Ho, P. S., Yonekura-Sakakibara, K., Sakakibara, H., and Mok, D. W. (2005) Plant Physiol., 137, 1057–1066.
Frebort, I., Kowalska, M., Hluska, T., Frebortova, J., and Galuszka, P. (2011) J. Exp. Bot., 62, 2431–2452.
Kravtsov, A. K., Zubo, Ya. O., Yamburenko, M. V., Kulaeva, O. N., and Kusnetsov, V. V. (2011) Plant Growth Regul., 64, 173–183.
Werner, T., Motyka, V., Strnad, M., and Schmulling, T. (2001) Proc. Natl. Acad. Sci. USA, 98, 10487–10492.
Bae, E., Bingman, C. A., Bitto, E., Aceti, D. J., and Phillips, G. N., Jr. (2008) Proteins, 70, 303–306.
Pils, B., and Heyl, A. (2009) Plant Physiol., 151, 782–791.
Smehilova, M., Galuszka, P., Bilyeu, K. D., Jaworek, P., Kowalska, M., Sebela, M., Sedlarova, M., English, J. T., and Frebort, I. (2009) J. Exp. Bot., 60, 2701–2712.
Werner, T., and Schmulling, T. (2009) Curr. Opin. Plant Biol., 12, 527–538.
Kaminek, M., Motyka, V., and Vankova, R. (1997) Physiol. Plant., 101, 689–700.
Werner, T., Kollmer, I., Bartrina, I., Holst, K., and Schmulling, T. (2006) Plant Biol., 8, 371–381.
Kopecny, D., Sebela, M., Briozzo, P., Spichal, L., Houba-Herin, N., Masek, V., Joly, N., Madzak, C., Anzenbacher, P., and Laloue, M. (2008) J. Mol. Biol., 380, 886–899.
Hare, P. D., and Van Staden, J. (1994) Physiol. Plant., 91, 128–136.
Jones, R. J., and Schreiber, B. M. N. (1997) Plant Growth Regul., 23, 123–134.
Galuszka, P., Frebort, I., Sebela, M., and Pec, P. (2000) Plant Growth Regul., 32, 315–327.
Veselov, S. Y., and Simonyan, M. V. (2004) Fiziol. Rast., 51, 297–302.
Zhang, J., Liu, W., Yang, X., Gao, A., Li, X., Wu, X., and Li, L. (2011) Mol. Biol. Rep., 38, 2337–2347.
Schmulling, T., Werner, T., Riefler, M., Krupkova, E., and Manns, I. B. (2003) J. Plant Res., 116, 241–252.
Galuszka, P., Popelkova, H., Werner, T., Frebortova, J., Pospisilova, H., Mik, V., Kollmer, I., Schmulling, T., and Frebort, I. (2007) J. Plant Growth Regul., 26, 255–267.
Kowalska, M., Galuszka, P., Frebortova, J., Sebela, M., Beres, T., Hluska, T., Smehilova, M., Bilyeu, K. D., and Frebort, I. (2010) Phytochemistry, 71, 1970–1978.
Paces, V., Werstiuk, E., and Hall, R. H. (1971) Plant Physiol., 48, 775–778.
Whitty, C. D., and Hall, R. H. (1974) Can. J. Biochem., 52, 787–799.
Galuszka, P., Frebort, I., Sebela, M., Sauer, P., Jacobsen, S., and Pec, P. (2001) Eur. J. Biochem., 268, 450–461.
Yang, S. H., Yu, H., and Goh, C. J. (2002) J. Exp. Bot., 53, 1899–1907.
Gerhauser, D., and Bopp, M. (1990) J. Plant Physiol., 135, 714–718.
Armstrong, D. J., and Firtel, R. A. (1989) Dev. Biol., 136, 491–499.
Van Kast, C. A., and Laten, H. (1987) Plant Physiol., 83, 726–727.
Chatfield, J. M., and Armstrong, D. J. (1988) Plant Physiol., 88, 245–247.
Laloue, M., and Fox, J. E. (1989) Plant Physiol., 90, 899–906.
Meilan, R., and Morris, R. O. (1994) Plant Physiol., 105 (Suppl.), 68.
Schreiber, B. M. N., Roessler, J. A., and Jones, R. J. (1995) Plant Physiol., 108 (Suppl.), 80.
Houba-Herin, N., Pethe, C., d’Alayer, J., and Laloue, M. (1999) Plant J., 17, 615–626.
Morris, R. O., Bilyeu, K. D., Laskey, J. G., and Cheikh, N. (1999) Biochem. Biophys. Res. Commun., 255, 328–333.
McGaw, B. A., and Horgan, R. (1983) Phytochemistry, 22, 1103–1105.
Brownlee, B. G., Hall, R. H., and Whitty, C. D. (1975) Can. J. Biochem., 53, 37–41.
Frebortova, J., Fraajie, M. W., Galuszka, P., Sebela, M., Pec, P., Hrbac, J., Novak, O., Bilyeu, K. D., English, J. T., and Frebort, I. (2004) Biochem. J., 380, 121–130.
Kopecny, D., Briozzo, P., Popelkova, H., Sebela, M., Koncitikova, R., Spichal, L., Nisler, J., Madzak, C., Frebort, I., Laloue, M., and Houba-Herin, N. (2010) Biochimie, 92, 1052–1062.
Malito, E., Coda, A., Bilyeu, K. D., Fraaije, M. W., and Mattevi, A. (2004) J. Mol. Biol., 341, 1237–1249.
Galuszka, P., Spichal, L., Kopecny, D., Tarkowski, P., Frebortova, J., Sebela, M., and Frebort, I. (2008) in Studies in Natural Products Chemistry, Vol. 34 (Atta-ur-Rahman, ed.) Elsevier, Amsterdam, pp. 203–264.
Gu, R., Fu, J., Guo, S., Duan, F., Wang, Z., Mi, G., and Yuan, L. (2010) J. Plant Growth Regul., 29, 428–440.
Ashikari, M., Sakakibara, H., Lin, Sh., Yamamoto, T., Takashi, T., Nishimura, A., Angeles, E. R., Qian, Q., Kitano, H., and Matsuoka, M. (2005) Science, 309, 741–745.
Vyroubalova, S., Vaclavikova, K., Tureckova, V., Novak, O., Smehilova, M., Hluska, T., Ohnoutkova, L., Frebort, I., and Galuszka, P. (2009) Plant Physiol., 151, 433–447.
Galuszka, P., Frebortova, J., Werner, T., Yamada, M., Strnad, M., Schmulling, T., and Frebort, I. (2004) Eur. J. Biochem., 271, 3990–4002.
Yang, S. H., Yu, H., and Goh, C. J. (2003) Plant Mol. Biol., 51, 237–248.
Zeng, Q.-W., Qin, S., Song, S.-Q., Zhang, M., Xiao, Y.-H., Luo, M., Hou, L., and Pei, Y. (2012) Plant Mol. Biol. Rep., 30, 1–9.
Gaudinova, A., Dobrev, P. I., Solcova, Bl., Novak, O., Strnad, M., Friedecky, D., and Motyka, V. (2005) J. Plant Growth Regul., 24, 188–200.
Vaseva-Gemisheva, I., Lee, D., and Karanov, E. (2005) Plant Growth Regul., 46, 199–208.
O’Keefe, D., Song, J., and Jameson, P. E. (2011) J. Plant Growth Regul., 30, 92–99.
Avalbaev, A. M., Yuldashev, R. A., Vysotskaya, L. B., and Shakirova, F. M. (2006) Dokl. Ros. Akad. Nauk, 410, 825–827.
Feng, D. S., Wang, H. G., Zhang, X. S., Kong, L. R., Tian, J. C., and Li, X. F. (2008) Plant Mol. Biol. Rep., 26, 143–155.
Mameaux, S., Cockram, J., Thiel, T., Steuernagel, B., Stein, N., Taudien, S., Jack, P., Werner, P., Gray, J. C., Greenland, A. J., and Powell, W. (2012) Plant Biotechnol. J., 10, 67–82.
Werner, T., Motyka, V., Laucou, V., Smets, R., Van Onckelen, H., and Schmulling, T. (2003) Plant Cell, 15, 2532–2550.
Miyawaki, K., Matsumoto-Kitano, M., and Kakimoto, T. (2004) Plant J., 37, 128–138.
Faiss, M., Zalubilova, J., Strnad, M., and Schmulling, T. (1997) Plant J., 12, 401–415.
Kulaeva, O. N., and Kuznetsov, V. V. (2002) Fiziol. Rast., 49, 626–640.
Kudo, T., Kiba, T., and Sakakibara, H. (2010) J. Integr. Plant Biol., 52, 53–60.
Massonneau, A., Houba-Herin, N., Pethe, C., Madzak, C., Falque, M., Mercy, M., Kopecny, D., Majira, A., Rogowsky, P., and Laloue, M. (2004) J. Exp. Bot., 55, 2549–2557.
Cheikh, N., and Jones, R. J. (1994) Plant Physiol., 106, 45–51.
Dietrich, J. T., Kaminek, M., Blevins, D. G., Reinbott, T. M., and Morris, R. O. (1995) Plant Physiol. Biochem., 33, 327–336.
Lur, H. S., and Setter, T. L. (1993) Plant Physiol., 103, 273–280.
Jones, R. J., Schreiber, B. M. N., McNeil, K., Brenner, M. L., Foxon, G. (1992) in Physiology and Biochemistry of Cytokinins in Plants (Kaminek, M., Mok, D. W. S., and Zazimalova, E., eds.) SPB Academic, The Hague, pp. 29–32.
Bilyeu, K. D., Cole, J. L., Laskey, J. G., Riekhof, W. R., Esparza, T. J., Kramer, M. D., and Morris, R. O. (2001) Plant Physiol., 125, 378–386.
Angra, R., Mandahar, C. L., and Gulati, A. (1990) Mycopathologia, 109, 177–182.
Turner, J. E., Mok, M. C., and Mok, D. W. S. (1985) Plant Physiol., 79, 321–322.
Mok, D. W., and Mok, M. C. (2001) Annu. Rev. Plant Physiol. Plant Mol. Biol., 52, 89–118.
Redig, P., Shaul, O., Inze, D., Van Montagu, M., and Van Onckelen, H. (1996) FEBS Lett., 391, 175–180.
Lohrmann, J., Sweere, U., Zabaleta, E., Bauerle, I., Keitel, C., Kozma-Bognar, L., Brennicke, A., Kudla, J., Schafer, E., and Harter, K. (2001) Mol. Gen. Genom., 265, 2–13.
Merewitz, E. B., Gianfagna, T., and Huang, B. (2011) J. Exp. Bot., 62, 5311–5333.
Schmulling, T., Schafer, S., and Romanov, G. (1997) Physiol. Plant., 100, 505–519.
Benkova, E., Witters, E., Van Dongen, W., Kola, J., Motyka, V., Brzobohat, B., Van Onckelen, H., and Machakova, I. (1999) Plant Physiol., 121, 245–251.
Frebortova, J., Novak, O., Frebort, I., and Jorda, R. (2010) Plant J., 61, 467–481.
Zalewski, W., Galuszka, P., Gasparis, S., Orczyk, W., and Nadolska-Orczyk, A. (2010) J. Exp. Bot., 61, 1839–1851.
Brugiere, N., Jiao, S., Hantke, S., Zinselmeier, C., Roessler, J. A., Niu, X., Jones, R. J., and Habben, J. E. (2003) Plant Physiol., 132, 1228–1240.
Galis, I., Bilyeu, K. D., Godinho, M. J. G., and Jameson, P. E. (2005) Plant Growth Regul., 45, 173–182.
Manju, R. V., Kulkarni, M. J., Prasad, T. G., Sudarshana, L., and Sashidhar, V. R. (2001) Indian J. Exp. Biol., 39, 786–792.
Munns, R., and Tester, M. (2008) Annu. Rev. Plant Biol., 59, 651–681.
Saavedra, X., Modrego, A., Rodriguez, D., Gonzalez-Garcia, M. P., Sanz, L., Nicolas, G., and Lorenzo, O. (2010) Plant Physiol., 152, 133–150.
Shakirova, F. M., Avalbaev, A. M., Bezrukova, M. V., and Kudoyarova, G. R. (2010) Plant Stress, 4, 32–38.
Vysotskaya, L. B., Korobova, A. V., Veselov, S. Y., Dodd, I. C., and Kudoyarova, G. R. (2009) Funct. Plant Biol., 36, 66–72.
Vysotskaya, L. B., Avalbaev, A. M., Yuldashev, R. A., Shakirova, F. M., Veselov, S. Y., and Kudoyarova, G. R. (2010) Fiziol. Rast., 57, 530–537.
Galuszka, P., Frebortova, J., Luhova, L., Bilyeu, K. D., English, J. T., and Frebort, I. (2005) Plant Cell Physiol., 46, 716–728.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © A. M. Avalbaev, K. A. Somov, R. A. Yuldashev, F. M. Shakirova, 2012, published in Biokhimiya, 2012, Vol. 77, No. 12, pp. 1621–1630.
Rights and permissions
About this article
Cite this article
Avalbaev, A.M., Somov, K.A., Yuldashev, R.A. et al. Cytokinin oxidase is key enzyme of cytokinin degradation. Biochemistry Moscow 77, 1354–1361 (2012). https://doi.org/10.1134/S0006297912120024
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0006297912120024