Skip to main content

Advertisement

SpringerLink
Log in

A-to-I RNA Editing: A Contribution to Diversity of the Transcriptome and an Organism’s Development

  • Review
  • Published:
Biochemistry (Moscow) Aims and scope Submit manuscript

Abstract

The complexity of multicellular organisms requires both an increase in genetic information and fine tuning in regulation of gene expression. One of the mechanisms responsible for these functions is RNA editing. RNA editing is a complex process affecting the mechanism of changes in transcriptome sequences. The best studied example of this process is A-to-I RNA editing. On the organism’s level, RNA editing plays a key role during ontogenesis and in the defense against pathogens. Disorders in A-to-I RNA editing lead to serious abnormalities. The importance of RNA editing increases with an increase in the organism’s complexity. Correct RNA editing is an indispensable factor of an organism’s development and probably determines the lifespan of higher eukaryotes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Licatalosi, D. D., and Darnell, R. B. (2010) Nat. Rev. Genet., 11, 75–87.

    Article  CAS  PubMed  Google Scholar 

  2. Gott, J. M., and Emeson, R. B. (2000) Annu. Rev. Genet., 34, 499–531.

    Article  CAS  PubMed  Google Scholar 

  3. Bass, B. L. (2002) Annu. Rev. Biochem., 71, 817–846.

    Article  CAS  PubMed  Google Scholar 

  4. Nishikura, K. (2010) Annu. Rev. Biochem., 79, 321–349.

    Article  CAS  PubMed  Google Scholar 

  5. Maas, S., Kawahara, Y., Tamburr, K. M., and Nishikura, K. (2006) RNA Biol., 3, 1–9.

    CAS  PubMed  Google Scholar 

  6. Montano, M., and Long, K. (2010) Ageing Res. Rev., doi: 10.1016/j.arr.2010.02.002.

  7. Jin, Y., Zhang, W., and Li, Q. (2009) IUBMB Life, 61, 572–578.

    Article  CAS  PubMed  Google Scholar 

  8. Cho, D. S., Yang, W., Lee, J. T., Shiekhattar, R., Murray, J. M., and Nishikura, K. (2003) J. Biol. Chem., 278, 17093–17102.

    Article  CAS  PubMed  Google Scholar 

  9. Macbeth, M. R., Schubert, H. L., Vandemark, A. P., Lingam, A. T., Hill, C. P., and Bass, B. L. (2005) Science, 309, 1534–1539.

    Article  CAS  PubMed  Google Scholar 

  10. Saunders, L. R., and Barber, G. N. (2003) FASEB J., 17, 961–983.

    Article  CAS  PubMed  Google Scholar 

  11. Maas, S., and Gommans, W. M. (2009) Nucleic Acids Res., 37, 5822–5829.

    Article  CAS  PubMed  Google Scholar 

  12. Schumacher, J. M., Lee, K., Edelhoff, S., and Braun, R. E. (1995) Biol. Reprod., 52, 1274–1283.

    Article  CAS  PubMed  Google Scholar 

  13. Athanasiadis, A., Rich, A., and Maas, S. (2004) PLoS Biol., 2, e391.

    Article  PubMed  Google Scholar 

  14. Rueter, S. M., Dawson, T. R., and Emeson, R. B. (1999) Nature, 399, 75–80.

    Article  CAS  PubMed  Google Scholar 

  15. Zhang, Z., and Carmichael, G. G. (2001) Cell, 106, 465–475.

    Article  CAS  PubMed  Google Scholar 

  16. Prasanth, K. V., Prasanth, S. G., Xuan, Z., Hearn, S., Freier, S. M., Bennett, C. F., Zhang, M. Q., and Spector, D. L. (2005) Cell, 123, 249–263.

    Article  CAS  PubMed  Google Scholar 

  17. Scadden, A. D., and Smith, C. W. (2001) EMBO J., 20, 4243–4252.

    Article  CAS  PubMed  Google Scholar 

  18. Pankratova, E. V., and Stepchenko, A. G. (2010) Genetika, 46, 5–13.

    CAS  PubMed  Google Scholar 

  19. Higuchi, M., Single, F. N., Kohler, M., Sommer, B., Sprengel, R., and Seeburg, P. H. (1993) Cell, 75, 1361–1370.

    Article  CAS  PubMed  Google Scholar 

  20. Seeburg, P. H., and Hartner, J. (2003) Curr. Opin. Neurobiol., 13, 279–283.

    Article  CAS  PubMed  Google Scholar 

  21. Burns, C. M., Chu, H., Rueter, S. M., Hutchinson, L. K., Canton, H., Sanders-Bush, E., and Emeson, R. B. (1997) Nature, 387, 303–308.

    Article  CAS  PubMed  Google Scholar 

  22. Wang, Q., O’Brien, P. J., Chen, C. X., Cho, D. S., Murray, J. M., and Nishikura, K. (2000) J. Neurochem., 74, 1290–1300.

    Article  CAS  PubMed  Google Scholar 

  23. Kawahara, Y., Megraw, M., Kreider, E., Iizasa, H., Valente, L., Hatzigeorgiou, A. G., and Nishikura, K. (2008) Nucleic Acids Res., 36, 5270–5280.

    Article  CAS  PubMed  Google Scholar 

  24. Yang, W., Chendrimada, T. P., Wang, Q., Higuchi, M., Seeburg, P. H., Shiekhattar, R., and Nishikura, K. (2006) Nat. Struct. Mol. Biol., 13, 13–21.

    Article  CAS  PubMed  Google Scholar 

  25. Scadden, A. D. (2005) Nat. Struct. Mol. Biol., 12, 489–496.

    Article  CAS  PubMed  Google Scholar 

  26. Heale, B. S., Keegan, L. P., McGurk, L., Michlewski, G., Brindle, J., Stanton, C. M., Caceres, J. F., and O’Connell, M. A. (2009) EMBO J., 28, 3145–3156.

    Article  CAS  PubMed  Google Scholar 

  27. Kawahara, Y., Zinshteyn, B., Chendrimada, T. P., Shiekhattar, R., and Nishikura, K. (2007) EMBO Rep., 8, 763–769.

    Article  CAS  PubMed  Google Scholar 

  28. Pillai, R. S., Bhattacharyya, S. N., and Filipowicz, W. (2007) Trends Cell Biol., 17, 118–126.

    Article  CAS  PubMed  Google Scholar 

  29. Baek, D., Villen, J., Shin, C., Camargo, F. D., Gygi, S. P., and Bartel, D. P. (2008) Nature, 455, 64–71.

    Article  CAS  PubMed  Google Scholar 

  30. Kawahara, Y., Zinshteyn, B., Sethupathy, P., Iizasa, H., Hatzigeorgiou, A. G., and Nishikura, K. (2007) Science, 315, 1137–1140.

    Article  CAS  PubMed  Google Scholar 

  31. Borchert, G. M., Gilmore, B. L., Spengler, R. M., Xing, Y., Lanier, W., Bhattacharya, D., and Davidson, B. L. (2009) Hum. Mol. Genet., 18, 4801–4807.

    Article  CAS  PubMed  Google Scholar 

  32. Tonkin, L. A., Saccomanno, L., Morse, D. P., Brodigan, T., Krause, M., and Bass, B. L. (2002) EMBO J., 21, 6025–6035.

    Article  CAS  PubMed  Google Scholar 

  33. Sebastiani, P., Montano, M., Puca, A., Solovieff, N., Kojima, T., Wang, M. C., Melista, E., Meltzer, M., Fischer, S. E., Andersen, S., Hartley, S. H., Sedgewick, A., Arai, Y., Bergman, A., Barzilai, N., Terry, D. F., Riva, A., Anselmi, C. V., Malovini, A., Kitamoto, A., Sawabe, M., Arai, T., Gondo, Y., Steinberg, M. H., Hirose, N., Atzmon, G., Ruvkun, G., Baldwin, C. T., and Perls, T. T. (2009) PLoS One, 4, e8210.

    Article  PubMed  Google Scholar 

  34. Tonkin, L. A., and Bass, B. L. (2003) Science, 302, 1725.

    Article  CAS  PubMed  Google Scholar 

  35. Palladino, M. J., Keegan, L. P., O’Connell, M. A., and Reenan, R. A. (2000) Cell, 102, 437–449.

    Article  CAS  PubMed  Google Scholar 

  36. Wang, Q., Khillan, J., Gadue, P., and Nishikura, K. (2000) Science, 290, 1765–1768.

    Article  CAS  PubMed  Google Scholar 

  37. Wang, Q., Miyakoda, M., Yang, W., Khillan, J., Stachura, D. L., Weiss, M. J., and Nishikura, K. (2004) J. Biol. Chem., 279, 4952–4961.

    Article  CAS  PubMed  Google Scholar 

  38. Higuchi, M., Maas, S., Single, F. N., Hartner, J., Rozov, A., Burnashev, N., Feldmeyer, D., Sprengel, R., and Seeburg, P. H. (2000) Nature, 406, 78–81.

    Article  CAS  PubMed  Google Scholar 

  39. Connolly, C. M., Dearth, A. T., and Braun, R. E. (2005) Dev. Biol., 278, 13–21.

    Article  CAS  PubMed  Google Scholar 

  40. Miyamura, Y., Suzuki, T., Kono, M., Inagaki, K., Ito, S., Suzuki, N., and Tomita, Y. (2003) Am. J. Hum. Genet., 73, 693–699.

    Article  CAS  PubMed  Google Scholar 

  41. Li, M., Yang, L., Li, C., Jin, C., Lai, M., Zhang, G., Hu, Y., Ji, J., and Yao, Z. (2010) Arch. Dermatol. Res., 302, 469–476.

    Article  CAS  PubMed  Google Scholar 

  42. Krestel, H. E., Shimshek, D. R., Jensen, V., Nevian, T., Kim, J., Geng, Y., Bast, T., Depaulis, A., Schonig, K., Schwenk, F., Bujard, H., Hvalby, O., Sprengel, R., and Seeburg, P. H. (2004) J. Neurosci., 24, 10568–10578.

    Article  CAS  PubMed  Google Scholar 

  43. Iwamoto, K., Bundo, M., and Kato, T. (2009) RNA Biol., 6, 248–253.

    Article  CAS  PubMed  Google Scholar 

  44. Gallo, A., and Galardi, S. (2008) RNA Biol., 5, 135–139.

    CAS  PubMed  Google Scholar 

  45. Beghini, A., Ripamonti, C. B., Peterlongo, P., Roversi, G., Cairoli, R., Morra, E., and Larizza, L. (2000) Hum. Mol. Genet., 9, 2297–2304.

    CAS  PubMed  Google Scholar 

  46. Maas, S., Patt, S., Schrey, M., and Rich, A. (2001) Proc. Natl. Acad. Sci. USA, 98, 14687–14692.

    Article  CAS  PubMed  Google Scholar 

  47. Cenci, C., Barzotti, R., Galeano, F., Corbelli, S., Rota, R., Massimi, L., Di Rocco, C., O’Connell, M. A., and Gallo, A. (2008) J. Biol. Chem., 283, 7251–7260.

    Article  CAS  PubMed  Google Scholar 

  48. George, C. X., and Samuel, C. E. (1999) Proc. Natl. Acad. Sci. USA, 96, 4621–4626.

    Article  CAS  PubMed  Google Scholar 

  49. George, C. X., Li, Z., Okonski, K. M., Toth, A. M., Wang, Y., and Samuel, C. E. (2009) J. Interferon Cytokine Res., 29, 477–487.

    Article  CAS  PubMed  Google Scholar 

  50. Polson, A. G., Bass, B. L., and Casey, J. L. (1996) Nature, 380, 454–456.

    Article  CAS  PubMed  Google Scholar 

  51. Casey, J. L. (2006) Curr. Top. Microbiol. Immunol., 307, 67–89.

    Article  CAS  PubMed  Google Scholar 

  52. Gandy, S. Z., Linnstaedt, S. D., Muralidhar, S., Cashman, K. A., Rosenthal, L. J., and Casey, J. L. (2007) J. Virol., 81, 13544–13551.

    Article  CAS  PubMed  Google Scholar 

  53. Phuphuakrat, A., Kraiwong, R., Boonarkart, C., Lauhakirti, D., Lee, T. H., and Auewarakul, P. (2008) J. Virol., 82, 10864–10872.

    Article  CAS  PubMed  Google Scholar 

  54. Lei, M., Liu, Y., and Samuel, C. E. (1998) Virology, 245, 188–196.

    Article  CAS  PubMed  Google Scholar 

  55. Liu, Y., Wolff, K. C., Jacobs, B. L., and Samuel, C. E. (2001) Virology, 289, 378–387.

    Article  CAS  PubMed  Google Scholar 

  56. Yang, J. H., Luo, X., Nie, Y., Su, Y., Zhao, Q., Kabir, K., Zhang, D., and Rabinovici, R. (2003) Immunology, 109, 15–23.

    Article  CAS  PubMed  Google Scholar 

  57. Hartner, J. C., Walkley, C. R., Lu, J., and Orkin, S. H. (2009) Nat. Immunol., 10, 109–115.

    Article  CAS  PubMed  Google Scholar 

  58. Barbon, A., Fumagalli, F., Caracciolo, L., Madaschi, L., Lesma, E., Mora, C., Carelli, S., Slotkin, T. A., Racagni, G., Di Giulio, A. M., Gorio, A., and Barlati, S. (2010) J. Neurochem., 114, 397–407.

    CAS  PubMed  Google Scholar 

  59. Fontana, L., Partridge, L., and Longo, V. D. (2010) Science, 328, 321–326.

    Article  CAS  PubMed  Google Scholar 

  60. Nilsen, T. W., and Graveley, B. R. (2010) Nature, 463, 457–463.

    Article  CAS  PubMed  Google Scholar 

  61. Schmucker, D., Clemens, J. C., Shu, H., Worby, C. A., Xiao, J., Muda, M., Dixon, J. E., and Zipursky, S. L. (2000) Cell, 101, 671–684.

    Article  CAS  PubMed  Google Scholar 

  62. Gott, J. M. (2003) Comptes Rendus Biol., 326, 901–908.

    Article  CAS  Google Scholar 

  63. Lewis, B. P., Burge, C. B., and Bartel, D. P. (2005) Cell, 120, 15–20.

    Article  CAS  PubMed  Google Scholar 

  64. Winter, J., Jung, S., Keller, S., Gregory, R. I., and Diederichs, S. (2009) Nat. Cell Biol., 11, 228–234.

    Article  CAS  PubMed  Google Scholar 

  65. Hundley, H. A., and Bass, B. L. (2010) Trends Biochem. Sci., 35, 377–383.

    Article  CAS  PubMed  Google Scholar 

  66. Alvarez-Garcia, I., and Miska, E. A. (2005) Development, 132, 4653–4662.

    Article  CAS  PubMed  Google Scholar 

  67. Fernando, P., and Megeney, L. A. (2007) FASEB J., 21, 8–17.

    Article  CAS  PubMed  Google Scholar 

  68. Yi, C. H., and Yuan, J. (2009) Dev. Cell., 16, 21–34.

    Article  CAS  PubMed  Google Scholar 

  69. Subramanian, S., and Steer, C. J. (2010) J. Cell Physiol., 223, 289–298.

    CAS  PubMed  Google Scholar 

  70. Nakagawa, A., Shi, Y., Kage-Nakadai, E., Mitani, S., and Xue, D. (2010) Science, 328, 327–334.

    Article  CAS  PubMed  Google Scholar 

  71. Toth, A. M., Li, Z., Cattaneo, R., and Samuel, C. E. (2009) J. Biol. Chem., 284, 29350–29356.

    Article  CAS  PubMed  Google Scholar 

  72. Sundstrom, J. F., Vaculova, A., Smertenko, A. P., Savenkov, E. I., Golovko, A., Minina, E., Tiwari, B. S., Rodriguez- Nieto, S., Zamyatnin, A. A., Jr., Valineva, T., Saarikettu, J., Frilander, M. J., Suarez, M. F., Zavialov, A., Stahl, U., Hussey, P. J., Silvennoinen, O., Sundberg, E., Zhivotovsky, B., and Bozhkov, P. V. (2009) Nat. Cell Biol., 11, 1347–1354.

    Article  PubMed  Google Scholar 

  73. Gommans, W. M., Mullen, S. P., and Maas, S. (2009) BioEssays, 31, 1137–1145.

    Article  CAS  PubMed  Google Scholar 

  74. Paz-Yaacov, N., Levanon, E. Y., Nevo, E., Kinar, Y., Harmelin, A., Jacob-Hirsch, J., Amariglio, N., Eisenberg, E., and Rechavi, G. (2010) Proc. Natl. Acad. Sci. USA, 107, 12174–12179.

    Article  CAS  PubMed  Google Scholar 

  75. Skulachev, V. P., and Longo, V. D. (2005) Ann. N. Y. Acad. Sci., 1057, 145–164.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Mitoengineering and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991, Moscow, Russia

    A. A. Jr Zamyatnin, K. G. Lyamzaev & R. A. Zinovkin

Authors
  1. A. A. Jr Zamyatnin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. G. Lyamzaev
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. A. Zinovkin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. A. Jr Zamyatnin.

Additional information

Original Russian Text © A. A. Zamyatnin, Jr., K. G. Lyamzaev, R. A. Zinovkin, 2010, published in Biokhimiya, 2010, Vol. 75, No. 11, pp. 1489–1498.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jr Zamyatnin, A.A., Lyamzaev, K.G. & Zinovkin, R.A. A-to-I RNA Editing: A Contribution to Diversity of the Transcriptome and an Organism’s Development. Biochemistry Moscow 75, 1316–1323 (2010). https://doi.org/10.1134/S0006297910110027

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0006297910110027

Key words

Search

Navigation