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Mechanisms controlling activation of the α-globin gene domain in chicken erythroid cells

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Abstract

In this review we consider the organization of the chicken α-globin gene domain and mechanisms regulating the activity of this tissue-specific gene domain located in a potentially active (characterized by an increased sensitivity to nucleases) chromatin configuration in cells of all lineages. Both regulatory mechanisms ensuring repression of α-globin genes in non-erythroid cells and mechanisms responsible for activation of transcription of these genes during erythroid cell differentiation are discussed. The analysis of the structure-function organization of the chicken α-globin gene domain presented in this review is based mainly on the authors’ own results obtained over the last 20 years. On discussing the hypotheses explaining the mechanisms controlling the functional activity of chicken α-globin gene domain, data obtained in studies of α-globin gene domains of other verte brates are also analyzed.

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Abbreviations

MAR:

matrix-associated region

kb:

thousand base pairs

References

  1. Ioudinkova, E. S., and Razin, S. V. (2002) Mol. Biol. (Moscow), 36, 947–955 (Russ.).

    Google Scholar 

  2. Ioudinkova, E.S., and Razin, S. V. (2003) Genetika, 39, 182–186.

    Google Scholar 

  3. Razin, S. V., Farrell, C. M., and Recillas-Targa, F. (2003) Int. Rev. Cytol., 226, 63–125.

    Article  PubMed  CAS  Google Scholar 

  4. Sjakste, N., Iarovaia, O. V., Razin, S. V., Linares-Cruz, G., Sjakste, T., Le Gac, V., Zhao, Z., and Scherrer, K. (2000) Mol. Gen. Genet., 262, 1012–1021.

    Article  PubMed  CAS  Google Scholar 

  5. Flint, J., Tufarelli, C., Peden, J., Clark, K., Daniels, R. J., Hardison, R., Miller, W., Philipsen, S., Tan-Un, K. C., McMorrow, T., Frampton, J., Alter, B. P., Frischauf, A. M., and Higgs, D. R. (2001) Hum. Mol. Genet., 10, 371–382.

    Article  PubMed  CAS  Google Scholar 

  6. Ioudinkova, E. S., and Razin, S. V. (1999) Mol. Biol. (Moscow), 33, 603–604 (Russ.).

    Google Scholar 

  7. Valadez-Graham, V., Razin, S. V., and Recillas-Targa, F. (2004) Nucleic Acids Res., 32, 1354–1362.

    Article  PubMed  CAS  Google Scholar 

  8. Kuhn, E. J., and Geyer, P. K. (2003) Curr. Opin. Cell. Biol., 15, 259–265.

    Article  PubMed  CAS  Google Scholar 

  9. Razin, S. V., de Moura Gallo, C. V., and Scherrer, K. (1994) Mol. Gen. Genet., 242, 649–652.

    Article  PubMed  CAS  Google Scholar 

  10. Anguita, E., Johnson, C. A., Wood, W. G., Turner, B. M., and Higgs, D. R. (2001) Proc. Natl. Acad. Sci. USA, 98, 12114–12119.

    Article  PubMed  CAS  Google Scholar 

  11. Imaizumi, M.-T., Diggelmann, H., and Scherrer, K. (1973) Proc. Natl. Acad. Sci. USA, 70, 1122–1126.

    Article  PubMed  CAS  Google Scholar 

  12. Broders, F., Zahraoui, A., and Scherrer, K. (1990) Proc. Natl. Acad. Sci. USA, 87, 503–507.

    Article  PubMed  CAS  Google Scholar 

  13. Razin, S. V., Rynditch, A., Borunova, V., Ioudinkova, E., Smalko, V., and Scherrer, K. (2004) J. Cell. Biochem., 92, 445–457.

    Article  PubMed  CAS  Google Scholar 

  14. Borunova, V. V., Iarovaia, O. V., Vassetzky, Y. S., and Razin, S. V. (2005) FEBS Lett., 579, 4746–4750.

    Article  PubMed  CAS  Google Scholar 

  15. Iarovaia, O. V., Razin, S. V., Linares-Cruz, G., Sjakste, N., and Scherrer, K. (2001) Exp. Cell Res., 270, 159–165.

    Article  PubMed  CAS  Google Scholar 

  16. Ioudinkova, E., Razin, S. V., Borunova, V., de Conto, F., Rynditch, A., and Scherrer, K. (2005) J. Cell. Biochem., 94, 529–539.

    Article  PubMed  CAS  Google Scholar 

  17. Travers, A. (1999) Proc. Natl. Acad. Sci. USA, 96, 13634–13637.

    Article  PubMed  CAS  Google Scholar 

  18. Sims, R. J., Belotserkovskaya, R., and Reinberg, D. (2004) Genes Dev., 18, 2437–2468.

    Article  PubMed  CAS  Google Scholar 

  19. Gerber, M., and Shilatifard, A. (2003) J. Biol. Chem., 278, 26303–26306.

    Article  PubMed  CAS  Google Scholar 

  20. Higgs, D. R., Wood, W. G., Jarman, A. P., Sharpe, J., Lida, J., Pretorius, I.-M., and Ayyub, H. (1990) Genes Dev., 4, 1588–1601.

    PubMed  CAS  Google Scholar 

  21. Gourdon, G., Sharpe, J. A., Higgs, D. R., and Wood, W. G. (1995) Blood, 86, 766–775.

    PubMed  CAS  Google Scholar 

  22. Wen, S. C., Roder, K., Hu, K. Y., Rombel, I., Gavva, N. R., Daftari, P., Kuo, Y. Y., Wang, C., and Shen, C. K. (2000) Mol. Cell. Biol., 20, 1993–2003.

    Article  PubMed  CAS  Google Scholar 

  23. Gribnau, G., Diderich, K., Pruzina, S., Calzolari, R., and Frazer, P. (2000) Mol. Cell. Biol., 5, 377–386.

    CAS  Google Scholar 

  24. Hanscombe, O., Whyatt, D., Fraser, P., Yannoutsos, N., Greaves, D., Dillon, N., and Grosveld, F. (1991) Genes Dev., 5, 1387–1394.

    PubMed  CAS  Google Scholar 

  25. Singal, R., van Wert, J. M., and Ferdinand, L., Jr. (2002) Blood, 100, 4217–4222.

    Article  PubMed  CAS  Google Scholar 

  26. Knezetic, J., and Felsenfeld, G. (1989) Mol. Cell. Biol., 9, 893–901.

    PubMed  CAS  Google Scholar 

  27. Recillas Targa, F., de Moura Gallo, C. V., Huesca, M., Scherrer, K., and Marcaud, L. (1993) Gene, 129, 229–237.

    Article  CAS  Google Scholar 

  28. Rincon-Arano, H., Valadez-Graham, V., Guerrero, G., Escamilla-Del-Arenal, M., and Recillas-Targa, F. (2005) J. Mol. Biol., 349, 961–975.

    Article  PubMed  CAS  Google Scholar 

  29. Vyas, P., Vickers, M. A., Picketts, D. J., and Higgs, D. R. (1995) Genomics, 29, 679–689.

    Article  PubMed  CAS  Google Scholar 

  30. Klochkov, D., Rincon-Arano, H., Ioudinkova, E. S., Valadez-Graham, V., Gavrilov, A., Recillas-Targa, F., and Razin, S. V. (2006) Mol. Cell. Biol., 26, 1589–1597.

    Article  PubMed  CAS  Google Scholar 

  31. Anguita, E., Hughes, J., Heyworth, C., Blobel, G. A., Wood, W. G., and Higgs, D. R. (2004) EMBO J., 23, 2841–2852.

    Article  PubMed  CAS  Google Scholar 

  32. Higgs, D. R., Garrick, D., Anguita, E., de Gobbi, M., Hughes, J., Muers, M., Vernimmen, D., Lower, K., Law, M., Argentaro, A., Deville, M. A., and Gibbons, R. (2005) Ann. N. Y. Acad. Sci., 1054, 92–102.

    Article  PubMed  CAS  Google Scholar 

  33. Higgs, D. R., Vernimmen, D., de Gobbi, M., Anguita, E., Hughes, J., Buckle, V., Iborra, F., Garrick, D., and Wood, W. G. (2006) Biochem. Soc. Symp., Vol. 73, Portland Press, Oxford, pp. 11–22.

    Google Scholar 

  34. Razin, S. V., Kekelidze, M. G., Lukanidin, E. M., Scherrer, K., and Georgiev, G. P. (1986) Nucleic Acids Res., 14, 8189–8207.

    Article  PubMed  CAS  Google Scholar 

  35. Verbovaia, L., and Razin, S. V. (1995) Gene, 166, 255–259.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Gene Biology, Russian Academy of Sciences, ul. Vavilova 34/5, 119334, Moscow, Russia

    S. V. Razin & E. S. Ioudinkova

  2. Biological Faculty, Lomonosov Moscow State University, 119992, Moscow, Russia

    S. V. Razin

Authors
  1. S. V. Razin
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  2. E. S. Ioudinkova
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Correspondence to S. V. Razin.

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Original Russion Text © S. V. Rozin, E. S. Ioudinkova, 2007, published in Biokhimiya, 2007, Vol. 72, No. 5, pp. 581–585.

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Razin, S.V., Ioudinkova, E.S. Mechanisms controlling activation of the α-globin gene domain in chicken erythroid cells. Biochemistry Moscow 72, 467–470 (2007). https://doi.org/10.1134/S000629790705001X

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  • DOI: https://doi.org/10.1134/S000629790705001X

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