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The role of cytoskeleton in glucose regulation

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Abstract

Cytoskeleton plays an important role in glucose regulation, mainly in the following three aspects. First, cytoskeleton regulates insulin secretion by guiding intracellular transport of insulin-containing vesicles and regulating release of insulin. Second, cytoskeleton is involved in insulin action by regulating distribution of insulin receptor substrate, GLUT4 translocation, and internalization of insulin receptor. In addition, cytoskeleton directs the intracellular distribution of glucose metabolism related enzymes including glycogen synthase and many glycolysis enzymes.

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Abbreviations

CaMK II:

calmodulin-dependent protein kinase II

CAP:

Cbl-associated protein

GLUT4:

glucose transporter 4

INSR:

insulin receptor

IRS:

insulin receptor substrate

LDCV:

large dense core vesicle

MAP-2:

microtubule associated protein 2

PI3K:

phosphatidylinositol 3-kinase

PKA:

AMP-dependent protein kinase

SNARE:

soluble N-ethylmaleimide-sensitive attachment protein receptor

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Authors and Affiliations

  1. National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China

    Zhuo Liu, Yong-Wei Zhang, Yong-Sheng Chang & Fu-De Fang

Authors
  1. Zhuo Liu
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  2. Yong-Wei Zhang
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  3. Yong-Sheng Chang
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  4. Fu-De Fang
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Corresponding authors

Correspondence to Yong-Sheng Chang or Fu-De Fang.

Additional information

Published in Russian in Biokhimiya, 2006, Vol. 71, No. 5, pp. 592–597.

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Liu, Z., Zhang, YW., Chang, YS. et al. The role of cytoskeleton in glucose regulation. Biochemistry (Moscow) 71, 476–480 (2006). https://doi.org/10.1134/S0006297906050026

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